Laminin γ-2 Antibody (E-1): sc-55457

Laminin γ-2 Antibody (E-1) is a mouse monoclonal IgG2b antibody that detects Laminin γ-2 in human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Laminin γ-2 is a vital component of the extracellular matrix, specifically within the basal lamina, where Laminin γ-2 plays a significant role in cell adhesion, differentiation, and migration. Laminin γ-2 is crucial for maintaining the structural integrity of tissues and facilitating communication between cells and their environment. Laminin γ-2 interacts with various receptors, including integrins and dystroglycan, which are essential for cellular signaling and tissue organization. Laminin γ-2 is particularly important during embryonic development, as Laminin γ-2 influences the migration and polarization of cells, ultimately contributing to the formation of functional tissues and organs. Abnormalities in Laminin γ-2 expression or function can lead to a range of diseases, including muscular dystrophies and other connective tissue disorders, highlighting Laminin γ-2′s importance in both health and disease. Anti-Laminin γ-2 antibody (E-1) provides a reliable tool for researchers studying this critical protein in various biological processes and disease states.

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Laminin γ-2 Antibody (E-1) References:

1. Targeted inactivation of murine laminin gamma2-chain gene recapitulates human junctional epidermolysis bullosa.  |  Meng, X., et al. 2003. J Invest Dermatol. 121: 720-31. PMID: 14632187
2. Keratinocyte-targeted expression of human laminin γ2 rescues skin blistering and early lethality of laminin γ2 deficient mice.  |  Adair-Kirk, TL., et al. 2012. PLoS One. 7: e45546. PMID: 23029085
3. Clinicopathological significance of MMP-7, laminin γ2 and EGFR expression at the invasive front of gastric carcinoma.  |  Sentani, K., et al. 2014. Gastric Cancer. 17: 412-22. PMID: 24048760
4. Amino-terminal fragments of laminin γ2 chain retract vascular endothelial cells and increase vascular permeability.  |  Sato, H., et al. 2014. Cancer Sci. 105: 168-75. PMID: 24238220
5. Serum monomeric laminin-γ2 as a novel biomarker for hepatocellular carcinoma.  |  Kiyokawa, H., et al. 2017. Cancer Sci. 108: 1432-1439. PMID: 28418226
6. Opposing Roles of Epidermal Integrins α3β1 and α9β1 in Regulation of mTLD/BMP-1-Mediated Laminin-γ2 Processing during Wound Healing.  |  Longmate, WM., et al. 2018. J Invest Dermatol. 138: 444-451. PMID: 28923241
7. Laminin γ2-enriched extracellular vesicles of oral squamous cell carcinoma cells enhance in vitro lymphangiogenesis via integrin α3-dependent uptake by lymphatic endothelial cells.  |  Wang, SH., et al. 2019. Int J Cancer. 144: 2795-2810. PMID: 30485433
8. Identification of laminin γ2 as a prognostic and predictive biomarker for determining response to gemcitabine-based therapy in pancreatic ductal adenocarcinoma.  |  Okada, Y., et al. 2021. Eur J Cancer. 146: 125-134. PMID: 33607476
9. Bulk and single-cell RNA sequencing reveal the contribution of laminin γ2 -CD44 to the immune resistance in lymphocyte-infiltrated squamous lung cancer subtype.  |  Song, T., et al. 2024. Heliyon. 10: e31299. PMID: 38803944
10. Functional Re-expression of laminin-5 in laminin-gamma2-deficient human keratinocytes modifies cell morphology, motility, and adhesion.  |  Gagnoux-Palacios, L., et al. 1996. J Biol Chem. 271: 18437-44. PMID: 8702488

The preferred Laminin γ-2 antibody is Laminin γ-2 Antibody (E-6): sc-28330.