Molecular structure of Lacto-N-tetraose, CAS Number: 14116-68-8
Lacto-N-tetraose (CAS 14116-68-8)
CAS Number:
14116-68-8
Molecular Weight:
707.63
Molecular Formula:
C26H45NO21
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Lacto-N-tetraose, also referred to as LNT, is a naturally occurring sugar molecule. This sugar is found in milk and other dairy products and has garnered attention in research, particularly in the realm of cancer investigation. In vitro studies have demonstrated its potential as an anti-cancer agent by inhibiting the growth of cancer cells. Furthermore, Lacto-N-tetraose has been explored due to its ability to lower blood glucose levels. While the precise mechanism of action is not yet fully understood, it is believed to impede glycolysis, the process of glucose breakdown for energy production. Additionally, it is thought to inhibit glycogen synthase, an enzyme involved in glycogen synthesis, the storage form of glucose.
Lacto-N-tetraose (CAS 14116-68-8) References
- Facile enzymatic conversion of lactose into lacto-N-tetraose and lacto-N-neotetraose. | Murata, T., et al. 1999. Glycoconj J. 16: 189-95. PMID: 10596893
- Galactose-limited fed-batch cultivation of Escherichia coli for the production of lacto-N-tetraose. | Baumgärtner, F., et al. 2015. Enzyme Microb Technol. 75-76: 37-43. PMID: 26047914
- Synthesis of fucosylated lacto-N-tetraose using whole-cell biotransformation. | Baumgärtner, F., et al. 2015. Bioorg Med Chem. 23: 6799-806. PMID: 26481658
- Inefficient Metabolism of the Human Milk Oligosaccharides Lacto-N-tetraose and Lacto-N-neotetraose Shifts Bifidobacterium longum subsp. infantis Physiology. | Özcan, E. and Sela, DA. 2018. Front Nutr. 5: 46. PMID: 29900174
- Preclinical safety evaluation of the human-identical milk oligosaccharide lacto-N-tetraose. | Phipps, KR., et al. 2018. Regul Toxicol Pharmacol. 99: 260-273. PMID: 30244042
- Lacto-N-tetraose synthesis by wild-type and glycosynthase variants of the β-N-hexosaminidase from Bifidobacterium bifidum. | Schmölzer, K., et al. 2019. Org Biomol Chem. 17: 5661-5665. PMID: 31094393
- The chemical synthesis of human milk oligosaccharides: Lacto-N-tetraose (Galβ1→3GlcNAcβ1→3Galβ1→4Glc). | Bandara, MD., et al. 2019. Carbohydr Res. 486: 107824. PMID: 31585319
- Safety of lacto-N-tetraose (LNT) as a novel food pursuant to Regulation (EU) 2015/2283. | , ., et al. 2019. EFSA J. 17: e05907. PMID: 32626198
- Physiological effects, biosynthesis, and derivatization of key human milk tetrasaccharides, lacto-N-tetraose, and lacto-N-neotetraose. | Zhu, Y., et al. 2022. Crit Rev Biotechnol. 42: 578-596. PMID: 34346270
- Weighted analysis of 2'-fucosyllactose, 3-fucosyllactose, lacto-N-tetraose, 3'-sialyllactose, and 6'-sialyllactose concentrations in human milk. | Conze, DB., et al. 2022. Food Chem Toxicol. 163: 112877. PMID: 35304182
- Transporter Engineering Enables the Efficient Production of Lacto-N-triose II and Lacto-N-tetraose in Escherichia coli. | Sugita, T. and Koketsu, K. 2022. J Agric Food Chem. 70: 5106-5114. PMID: 35426313
- Safety of lacto-N-tetraose (LNT) produced by derivative strains of Escherichia coli BL21 (DE3) as a Novel Food pursuant to Regulation (EU) 2015/2283. | , ., et al. 2022. EFSA J. 20: e07242. PMID: 35600267
- Pathway Optimization and Uridine 5'-Triphosphate Regeneration for Enhancing Lacto-N-Tetraose Biosynthesis in Engineered Escherichia coli. | Li, Z., et al. 2022. J Agric Food Chem. 70: 7727-7735. PMID: 35723433
- Engineering Escherichia coli for the High-Titer Biosynthesis of Lacto-N-tetraose. | Hu, M., et al. 2022. J Agric Food Chem. 70: 8704-8712. PMID: 35731707
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lacto-N-tetraose, 1 mg | sc-286123 | 1 mg | $110.00 | |||
Lacto-N-tetraose, 2 mg | sc-286123A | 2 mg | $131.00 |