L-703,606 oxalate CAS: 351351-06-9
MF: C27H29N2I•C2H2O4
MW: 598.50
A selective nonpeptide NK1 tachykinin receptor antagonist.

L-703,606 oxalate (CAS 351351-06-9)

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Synonym: cis-2-(Diphenylmethyl)-N-[(2-iodophenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine oxalate salt
Application: A selective nonpeptide NK1 tachykinin receptor antagonist
CAS Number: 351351-06-9
Molecular Weight: 598.50
Molecular Formula: C27H29N2I•C2H2O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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L-703,606 oxalate is a potent and selective non-peptide NK-1R (NK1 tachykinin receptor) antagonist.


Characterization of the binding of a potent, selective, radioiodinated antagonist to the human neurokinin-1 receptor: M.A. Cascieri, et al.; Mol. Pharmacol. 42, 458 (1992) Localization of agonist and antagonist binding domains of the human neurokinin-1 receptor: T.M. Fong, et al.; J. Biol. Chem. 267, 25664 (1992)

Physical State :
Solubility :
Soluble in methanol, DMSO, and water (slightly).
Storage :
Store at 4° C
Boiling Point :
712.4° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
NK-1R: IC50 = 1.6 nM (human); NK-1R: EC5050 = 24.4 nM (human); Plasmodium falciparum: IC50 = 1.58 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
C1CN2CCC1[[email protected]]([[email protected]]2C(C3=CC=CC=C3)C4=CC=CC=C4)NCC5=CC=CC=C5I.C(=O)(C(=O)O)O

Download SDS (MSDS)

Certificate of Analysis

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