KRCC1 Antibody (B-4): sc-390411

KRCC1 Antibody (B-4) is a mouse monoclonal IgG3 kappa light chain antibody that detects KRCC1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-KRCC1 antibody (B-4) is available as the non-conjugated form. KRCC1, also known as lysine-rich coiled-coil 1 or cryptogenic hepatitis-binding protein 2, is a 259 amino acid protein encoded by a gene located on human chromosome 2p11.2. KRCC1 plays a crucial role in cellular processes, particularly in gene expression regulation and cellular signaling pathways. KRCC1′s coiled-coil structure facilitates protein-protein interactions, essential for forming multiprotein complexes that influence various biological functions, including cell proliferation and differentiation. KRCC1′s interactions with specific proteins can impact cellular responses to external stimuli, making KRCC1 a vital component in understanding disease mechanisms and potential therapeutic targets. Additionally, chromosome 2, where KRCC1 resides, is the second largest human chromosome and is associated with numerous genetic disorders, highlighting KRCC1′s importance in human health and disease research.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

KRCC1 Antibody (B-4) References:

1. Alstrom syndrome: confirmation of linkage to chromosome 2p12-13 and phenotypic heterogeneity in three affected sibs.  |  Zumsteg, U., et al. 2000. J Med Genet. 37: E8. PMID: 10882760
2. An ATP-binding cassette gene (ABCG5) from the ABCG (White) gene subfamily maps to human chromosome 2p21 in the region of the Sitosterolemia locus.  |  Shulenin, S., et al. 2001. Cytogenet Cell Genet. 92: 204-8. PMID: 11435688
3. Mutation of ALMS1, a large gene with a tandem repeat encoding 47 amino acids, causes Alström syndrome.  |  Hearn, T., et al. 2002. Nat Genet. 31: 79-83. PMID: 11941370
4. Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis.  |  Kelsell, DP., et al. 2005. Am J Hum Genet. 76: 794-803. PMID: 15756637
5. Punctuated duplication seeding events during the evolution of human chromosome 2p11.  |  Horvath, JE., et al. 2005. Genome Res. 15: 914-27. PMID: 15965031
6. Genome-wide association meta-analysis for total serum bilirubin levels.  |  Johnson, AD., et al. 2009. Hum Mol Genet. 18: 2700-10. PMID: 19414484
7. An alphoid DNA sequence conserved in all human and great ape chromosomes: evidence for ancient centromeric sequences at human chromosomal regions 2q21 and 9q13.  |  Baldini, A., et al. 1993. Hum Genet. 90: 577-83. PMID: 8444464
8. Mapping a gene involved in regulating dietary cholesterol absorption. The sitosterolemia locus is found at chromosome 2p21.  |  Patel, SB., et al. 1998. J Clin Invest. 102: 1041-4. PMID: 9727073

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KRCC1 Antibody (B-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-KRCC1 Antibody (B-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KRCC1 Antibody (B-4) Specifications

Alternate Product Name: KRCC1

Product Clone Name: B-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 39-71

Epitope Target: KRCC1

Epitope Species: human

Product Reactivity/Detection: KRCC1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for KRCC1 Antibody (B-4): P: Blocking Peptide