Molecular structure of Kinetin riboside, CAS Number: 4338-47-0
Kinetin riboside (CAS 4338-47-0)
Alternate Names:
6-Furfurylaminopurine riboside
Application:
Kinetin riboside is upregulates CDKN1A, causes depletion of ATP, causes a cell cycle arrest at the G2/M phase, and activates caspase-3
CAS Number:
4338-47-0
Purity:
≥97%
Molecular Weight:
347.33
Molecular Formula:
C15H17N5O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Kinetin riboside is an anti-proliferative agent which induces apoptosis in certain cell lines. Mechanistic studies show that Kinetin riboside upregulates CDKN1A, causes depletion of ATP, and causes a cell cycle arrest at the G2/M phase. Further studies suggest that Kinetin riboside also disrupts the mitochondrial membrane potential, induces the release of cytochrome c, activates caspase-3, upregulates Bad and down-regulates Bcl-2.
Kinetin riboside (CAS 4338-47-0) References
- Cytokinins that inhibit transfer RNA methylating enzymes. | Wainfan, E. and Landsberg, B. 1971. FEBS Lett. 19: 144-148. PMID: 11946197
- Identification of kinetin and kinetin riboside in coconut (Cocos nucifera L.) water using a combined approach of liquid chromatography-tandem mass spectrometry, high performance liquid chromatography and capillary electrophoresis. | Ge, L., et al. 2005. J Chromatogr B Analyt Technol Biomed Life Sci. 829: 26-34. PMID: 16216563
- Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells. | Choi, BH., et al. 2008. Cancer Lett. 261: 37-45. PMID: 18162289
- Identification of kinetin riboside as a repressor of CCND1 and CCND2 with preclinical antimyeloma activity. | Tiedemann, RE., et al. 2008. J Clin Invest. 118: 1750-64. PMID: 18431519
- Inhibitory effect of kinetin riboside in human heptamoa, HepG2. | Cheong, J., et al. 2009. Mol Biosyst. 5: 91-8. PMID: 19081935
- The experimental chemotherapeutic N6-furfuryladenosine (kinetin-riboside) induces rapid ATP depletion, genotoxic stress, and CDKN1A(p21) upregulation in human cancer cell lines. | Cabello, CM., et al. 2009. Biochem Pharmacol. 77: 1125-38. PMID: 19186174
- Simultaneous determination of different endogenetic plant growth regulators in common green seaweeds using dispersive liquid-liquid microextraction method. | Gupta, V., et al. 2011. Plant Physiol Biochem. 49: 1259-63. PMID: 22000048
- Antiproliferative activity of kinetin riboside on HCT-15 colon cancer cell line. | Rajabi, M., et al. 2012. Nucleosides Nucleotides Nucleic Acids. 31: 474-81. PMID: 22646087
- Kinetin Riboside and Its ProTides Activate the Parkinson's Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization. | Osgerby, L., et al. 2017. J Med Chem. 60: 3518-3524. PMID: 28323427
- Natural plant hormones cytokinins increase stress resistance and longevity of Caenorhabditis elegans. | Kadlecová, A., et al. 2018. Biogerontology. 19: 109-120. PMID: 29255944
- Circumventing the Crabtree effect: forcing oxidative phosphorylation (OXPHOS) via galactose medium increases sensitivity of HepG2 cells to the purine derivative kinetin riboside. | Orlicka-Płocka, M., et al. 2020. Apoptosis. 25: 835-852. PMID: 32955614
- Absolute oral and subcutaneous bioavailability of ortho-topolin riboside in mice. | Won, J., et al. 2021. J Pharm Biomed Anal. 206: 114363. PMID: 34521037
- Kinetin stimulates differentiation of C2C12 myoblasts. | Mielcarek, M. and Isalan, M. 2021. PLoS One. 16: e0258419. PMID: 34644361
- Endotoxin-enhanced host resistance: reversal by kinetin riboside. | Kessel, RW. and Braun, W. 1966. Nature. 211: 1001-2. PMID: 4961272
- The role of the epidermis in local lesion formation and the multiplication of tobacco mosaic virus and its relation to kinetin. | Kasamo, K. and Shimomura, T. 1977. Virology. 76: 12-8. PMID: 835224
Inhibitor of:
DCL-1.Activator of:
caspase-3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Kinetin riboside, 500 mg | sc-221789 | 500 mg | $141.00 | |||
Kinetin riboside, 5 g | sc-221789A | 5 g | $694.00 |