KCTD20 Antibody (B-11): sc-515219

KCTD20 Antibody (B-11) is a mouse monoclonal IgA antibody that detects KCTD20 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-KCTD20 antibody (B-11) is available as the non-conjugated form. KCTD20, also known as BTB/POZ domain-containing protein KCTD20 or C6orf69, is a 419 amino acid protein that plays a crucial role in cellular signaling by forming a complex with MARK4, which is involved in the regulation of microtubule dynamics and cell polarity. This interaction is particularly important for maintaining proper cellular function and organization, as disruptions in microtubule stability can lead to various diseases, including cancer and neurodegenerative disorders. KCTD20 is encoded by a gene located on human chromosome 6p21.31 and mouse chromosome 17 A3.3, which is significant given that chromosome 6 harbors approximately 1,200 genes and is associated with various genetic conditions, including early onset intestinal cancer and porphyria cutanea tarda. KCTD20 and its interactions within the cellular environment underscore its potential as a biomarker for disease and a target for therapeutic intervention.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

KCTD20 Antibody (B-11) References:

1. Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27.  |  Cesari, R., et al. 2003. Proc Natl Acad Sci U S A. 100: 5956-61. PMID: 12719539
2. Recurrent deletions at 6q in early age of onset non-HNPCC- and non-FAP-associated intestinal carcinomas. Evidence for a novel cancer susceptibility locus at 6q14-q22.  |  Bläker, H., et al. 2008. Genes Chromosomes Cancer. 47: 159-64. PMID: 18008368
3. Linkage disequilibrium mapping of the chromosome 6q21-22.31 bipolar I disorder susceptibility locus.  |  Fan, J., et al. 2010. Am J Med Genet B Neuropsychiatr Genet. 153B: 29-37. PMID: 19308960
4. Associations among behavior-related susceptibility factors in porphyria cutanea tarda.  |  Jalil, S., et al. 2010. Clin Gastroenterol Hepatol. 8: 297-302, 302.e1. PMID: 19948245
5. A Stickler syndrome gene is linked to chromosome 6 near the COL11A2 gene.  |  Brunner, HG., et al. 1994. Hum Mol Genet. 3: 1561-4. PMID: 7833911

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KCTD20 Antibody (B-11) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-KCTD20 Antibody (B-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KCTD20 Antibody (B-11) Specifications

Alternate Product Name: KCTD20

Product Clone Name: B-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgA lambda light chain

Amino Acids: 33-58

Epitope Target: KCTD20

Epitope Species: human

Product Reactivity/Detection: KCTD20

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgA lambda light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for KCTD20 Antibody (B-11): P: Blocking Peptide