KANK1 Antibody (177D2T): sc-517629

KANK1 Antibody (177D2T) is a mouse monoclonal IgG1 kappa light chain antibody that detects KANK1 protein of human origin by western blotting (WB), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-KANK1 antibody (177D2T) is available as a non-conjugated format. KANK1, also known as KN motif and ankyrin repeat domains 1 or ANKRD15, is a crucial 1,352 amino acid protein characterized by five ankyrin (ANK) repeat domains, which play a significant role in protein-protein interactions. The structure of KANK1 is essential for function, as ANK domains facilitate binding to various signaling proteins, including 14-3-3 and IRSp53. These interactions regulate cellular processes such as insulin signaling and cell migration. KANK1′s ability to inhibit RhoA activity prevents formation of actin stress fibers, influencing cell shape and motility. KANK1′s regulation of cell polarity during directed migration supports processes like wound healing. Mutations in KANK1 can lead to cerebral palsy, spastic quadriplegic 2 (CPSQ2), highlighting KANK1′s significance in the developing nervous system. KANK1 (177D2T) antibody serves as an invaluable tool for researchers studying these pathways and implications of KANK1 in various cellular functions and disorders.

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KANK1 Antibody (177D2T) References:

1. Pathological characterization of Kank in renal cell carcinoma.  |  Roy, BC., et al. 2005. Exp Mol Pathol. 78: 41-8. PMID: 15596059
2. Alternative splicing of the human Kank gene produces two types of Kank protein.  |  Wang, Y., et al. 2005. Biochem Biophys Res Commun. 330: 1247-53. PMID: 15823577
3. Nucleo-cytoplasmic shuttling of human Kank protein accompanies intracellular translocation of beta-catenin.  |  Wang, Y., et al. 2006. J Cell Sci. 119: 4002-10. PMID: 16968744
4. Kank regulates RhoA-dependent formation of actin stress fibers and cell migration via 14-3-3 in PI3K-Akt signaling.  |  Kakinuma, N., et al. 2008. J Cell Biol. 181: 537-49. PMID: 18458160
5. Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1.  |  Roy, BC., et al. 2009. J Cell Biol. 184: 253-67. PMID: 19171758
6. KANK1, a candidate tumor suppressor gene, is fused to PDGFRB in an imatinib-responsive myeloid neoplasm with severe thrombocythemia.  |  Medves, S., et al. 2010. Leukemia. 24: 1052-5. PMID: 20164854
7. Effects of brefeldin A-inhibited guanine nucleotide-exchange (BIG) 1 and KANK1 proteins on cell polarity and directed migration during wound healing.  |  Li, CC., et al. 2011. Proc Natl Acad Sci U S A. 108: 19228-33. PMID: 22084092
8. Familial KANK1 deletion that does not follow expected imprinting pattern.  |  Vanzo, RJ., et al. 2013. Eur J Med Genet. 56: 256-9. PMID: 23454270
9. Upregulation of the Kank1 gene-induced brain glioma apoptosis and blockade of the cell cycle in G0/G1 phase.  |  Guo, X., et al. 2014. Int J Oncol. 44: 797-804. PMID: 24399197