Juglone inhibits the transcription of Pol II (RNA polymerase II) by changing the sulfhydryl groups and blocking the assembly of the preinitiation complex. Other studies show that Juglone does not block T7 RNA polymerase but that it inhibits Pol II and Pol III (RNA polymerase II and III). Human Pin1, Escherichia coli parvulin, and the yeast Ess1/Ptf1 have been shown to be blocked specifically and irreversibly by Juglone. Additionally, Juglone is an antifibrotic compound and promotes apoptosis via the mitochondrial-dependent pathway. Juglone is an inhibitor of Cyclophilin and Pin4.
1. Hennig, L., et al. 1998. Biochemistry. 37: 5953-5960. PMID: 9558330 2. Chao, S.H., et al. 2001. Nucleic Acids Res. 29: 767-773. PMID: 11160900 3. Ji, Y.B., et al. 2009. Exp. Toxicol. Pathol. [Epub ahead of print]. PMID: 19815401 4. Xu, H.L., et al. 2010. Eur. J. Pharmacol. 645: 14-22. PMID: 20655907 5. Reese, S., et al. 2010. Fibrogenesis Tissue Repair. 3: 1. PMID: 20047646
Soluble in DMSO (10 mg/ml), ethanol (10 mg/ml), benzene (Freely soluble), chloroform (Freely soluble), ether, aqueous solution of alkalies, and hot water.
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Answered by: Technical Support
Date published: 2017-07-31
Soy un investigador Chileno y me gustaría adquirir la molécula. Quisiera solicitar orientación sobre la forma de compra y si hacen envíos internacionales.
Asked by: Jorge Olivares
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RippmannRippmann, F. et al. (PubMed 10939594) used Juglone, a compound that inhibits the transcription of RNA polymerase II, to determine whether Pin1 regulates the G2-M transition and/or progression through mitosis in tumor cells. They found that the catalytic activity of Pin1 is essential for tumor cell survival and entry into mitosis. -SCBT Publication Review
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