Molecular structure of J 113863, CAS Number: 353791-85-2
J 113863 (CAS 353791-85-2)
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Alternate Names:
1,4-cis-1-(1-Cycloocten-1-ylmethyl)-4-[[(2,7-dichloro-9H-xanthen-9-yl)carbonyl]amino]-1-ethylpiperidinium iodide
Application:
J 113863 is a potent CCR1 chemokine receptor antagonist
CAS Number:
353791-85-2
Purity:
≥98%
Molecular Weight:
655.44
Molecular Formula:
C30H37Cl2IN2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
J 113863 is in biochemistry focused on the study of chemokine receptors, particularly as a potent antagonist of the CCR2 (chemokine receptor type 2). J 113863 is instrumental in elucidating the role of CCR2 in immune cell migration and inflammation. Some employ J 113863 to explore the molecular mechanisms underlying chemokine-driven pathologies and to investigate how modulation of CCR2 can influence immune system behavior. The insights gained from studies using J 113863 contribute to a better understanding of inflammatory processes and immune response regulation. J 113863 is used to examine the potential for targeting chemokine receptors in managing conditions characterized by excessive inflammatory responses.
J 113863 (CAS 353791-85-2) References
- A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry. | Sabroe, I., et al. 2000. J Biol Chem. 275: 25985-92. PMID: 10854442
- Pharmacological blockade of CCR1 ameliorates murine arthritis and alters cytokine networks in vivo. | Amat, M., et al. 2006. Br J Pharmacol. 149: 666-75. PMID: 17016504
- Spinal CCL2 and microglial activation are involved in paclitaxel-evoked cold hyperalgesia. | Pevida, M., et al. 2013. Brain Res Bull. 95: 21-7. PMID: 23562605
- Chemokine (C-C Motif) receptor 1 is required for efficient recruitment of neutrophils during respiratory infection with modified vaccinia virus Ankara. | Price, PJ., et al. 2014. J Virol. 88: 10840-50. PMID: 25008920
- Modified Vaccinia virus Ankara but not vaccinia virus induces chemokine expression in cells of the monocyte/macrophage lineage. | Lehmann, MH., et al. 2015. Virol J. 12: 21. PMID: 25889495
- Partial Agonist and Biased Signaling Properties of the Synthetic Enantiomers J113863/UCB35625 at Chemokine Receptors CCR2 and CCR5. | Corbisier, J., et al. 2017. J Biol Chem. 292: 575-584. PMID: 27895119
- Hyperalgesic and hypoalgesic mechanisms evoked by the acute administration of CCL5 in mice. | González-Rodríguez, S., et al. 2017. Brain Behav Immun. 62: 151-161. PMID: 28126501
- Involvement of Macrophage Inflammatory Protein-1 Family Members in the Development of Diabetic Neuropathy and Their Contribution to Effectiveness of Morphine. | Rojewska, E., et al. 2018. Front Immunol. 9: 494. PMID: 29593735
- The Chemokine CCL4 (MIP-1β) Evokes Antinociceptive Effects in Mice: a Role for CD4+ Lymphocytes and Met-Enkephalin. | García-Domínguez, M., et al. 2019. Mol Neurobiol. 56: 1578-1595. PMID: 29907903
- The blockade of CC chemokine receptor type 1 influences the level of nociceptive factors and enhances opioid analgesic potency in a rat model of neuropathic pain. | Pawlik, K., et al. 2020. Immunology. 159: 413-428. PMID: 31919846
- The analgesic properties of Yu-Xue-Bi tablets in the inflammatory pain mice: By the inhibition of CCL3-mediated macrophage transmigration into the spinal cord. | Zhang, G., et al. 2022. J Ethnopharmacol. 289: 115051. PMID: 35101573
- CCR1 antagonist ameliorates experimental autoimmune encephalomyelitis by inhibition of Th9/Th22-related markers in the brain and periphery. | Al-Mazroua, HA., et al. 2022. Mol Immunol. 144: 127-137. PMID: 35219910
- CCR1 antagonist J-113863 corrects the imbalance of pro- and anti-inflammatory cytokines in a SJL/J mouse model of relapsing-remitting multiple sclerosis. | Ansari, MA., et al. 2022. Immunobiology. 227: 152245. PMID: 35868215
- JAK inhibition ameliorates bone destruction by simultaneously targeting mature osteoclasts and their precursors. | Yari, S., et al. 2023. Inflamm Regen. 43: 18. PMID: 36869390
- Pharmacological Modulation of the MIP-1 Family and Their Receptors Reduces Neuropathic Pain Symptoms and Influences Morphine Analgesia: Evidence from a Mouse Model. | Ciechanowska, A., et al. 2023. Brain Sci. 13: PMID: 37190544
Inhibitor of:
CKR-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
J 113863, 1 mg | sc-203611 | 1 mg | $107.00 | |||
| US: Only available in the US | ||||||
J 113863, 10 mg | sc-203611A | 10 mg | $440.00 | |||
| US: Only available in the US | ||||||