Integrin αV/β3/CD51/CD61 Antibody (23C6): sc-7312

Integrin αV/β3 Antibody (23C6) is a mouse monoclonal IgG1 kappa light chain antibody that detects Integrin αV/β3 across multiple species including mouse, rat, human, African green monkey, Cynomolgus (Macaca fascicularis), chicken, bovine, rabbit, and porcine, through immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Anti-Integrin αV/β3 antibody (23C6) is available in both conjugated and non-conjugated forms, offering flexibility for various experimental needs. Integrins, including αV/β3, are essential for mediating cell adhesion and play a significant role in cellular signaling pathways. The structure of Integrin αV/β3, as a heterodimer composed of noncovalently associated α and β subunits, enables binding of diverse ligands from the extracellular matrix, such as fibronectin and vitronectin, as well as soluble ligands like fibrinogen. This structural diversity allows integrins to participate in cell migration, proliferation, and survival, making these proteins vital for tissue development and repair. Integrin αV/β3′s interaction with other proteins, such as intracellular adhesion molecules (ICAMs), highlights its importance in cell-cell interactions and immune response. Using Integrin αV/β3 (23C6) antibody in research provides valuable insights into cell adhesion and signaling mechanisms, which are fundamental to understanding various physiological and pathological processes.

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Integrin αV/β3/CD51/CD61 Antibody (23C6) References:

1. Integrins: versatility, modulation, and signaling in cell adhesion.  |  Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
2. RGD-based PET tracers for imaging receptor integrin αv β3 expression.  |  Cai, H. and Conti, PS. 2013. J Labelled Comp Radiopharm. 56: 264-79. PMID: 24285371
3. Cancer-associated fibroblast (CAF)-derived IL32 promotes breast cancer cell invasion and metastasis via integrin β3-p38 MAPK signalling.  |  Wen, S., et al. 2019. Cancer Lett. 442: 320-332. PMID: 30391782
4. Interleukin-8 promotes integrin β3 upregulation and cell invasion through PI3K/Akt pathway in hepatocellular carcinoma.  |  Sun, F., et al. 2019. J Exp Clin Cancer Res. 38: 449. PMID: 31684995
5. Integrin β3 promotes cardiomyocyte proliferation and attenuates hypoxia-induced apoptosis via regulating the PTEN/Akt/mTOR and ERK1/2 pathways.  |  Wei, L., et al. 2020. Int J Biol Sci. 16: 644-654. PMID: 32025212
6. Integrin β3-PKM2 pathway-mediated aerobic glycolysis contributes to mechanical ventilation-induced pulmonary fibrosis.  |  Mei, S., et al. 2022. Theranostics. 12: 6057-6068. PMID: 36168620
7. Blockage of Osteopontin-Integrin β3 Signaling in Infrapatellar Fat Pad Attenuates Osteoarthritis in Mice.  |  Dai, B., et al. 2023. Adv Sci (Weinh). 10: e2300897. PMID: 37218542
8. Platelet-derived microparticles adoptively transfer integrin β3 to promote antitumor effect of tumor-infiltrating T cells.  |  Zhou, M., et al. 2024. Oncoimmunology. 13: 2304963. PMID: 38235317
9. Integrins and signal transduction pathways: the road taken.  |  Clark, EA. and Brugge, JS. 1995. Science. 268: 233-9. PMID: 7716514
10. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function.  |  Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
11. Epithelial integrins.  |  Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
12. Cooperation between soluble factors and integrin-mediated cell anchorage in the control of cell growth and differentiation.  |  Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Integrin αV/β3/CD51/CD61 Antibody (23C6) has 112 citations in a variety of scientific publications.

Primary antibodies like Anti-Integrin αV/β3/CD51/CD61 Antibody (23C6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Integrin αV/β3/CD51/CD61 Antibody (23C6) Specifications

Alternate Product Name: CD51/CD61

Product Clone Name: 23C6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: Integrin αV/β3

Epitope Species: human

Product Reactivity/Detection: Integrin αV/β3

Species Reactivity/Detection: mouse, rat, human, African green monkey, Cynomolgus (Macaca fascicularis), chicken, bovine, rabbit, porcine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 112 citations in various scientific publications

Available Conjugates/Forms for Integrin αV/β3/CD51/CD61 Antibody (23C6): AF405: Alexa Fluor^® 405, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, PE: Phycoerythrin