IKK-ε Antibody (C-9): sc-365830
- IKK-ε Antibody (C-9) is a mouse monoclonal IgG3 κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-24 at the N-terminus of IKK-ε of human origin
- recommended for detection of IKK-ε of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IKK-ε Antibody (C-9). This work is in progress.
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IKK-ε Antibody (C-9) is a mouse monoclonal IgG3 antibody that detects IKK-ε in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IKK-ε, also known as IKBKE, is a serine/threonine kinase that plays a crucial role in the immune response by regulating the activation of the transcription factor NFκB. IKK-ε is primarily expressed in immune cells and is induced by stimuli such as lipopolysaccharide and proinflammatory cytokines, including TNFα, IL-1, and IL-6. IKK-ε phosphorylates IκBα at specific serine residues, leading to the degradation of IκB and subsequent release and activation of NFκB. This process is vital for the transcriptional regulation of genes involved in inflammation and immune responses. IKK-ε shares homology with other members of the IKK family, such as IKKα and IKKβ, and IKK-ε overexpression has been linked to enhanced phosphorylation of IκBα, indicating a potential role as an IκB kinase in the immune system. Anti-IKK-ε antibody (C-9) is an essential tool for researchers studying the mechanisms of NFκB activation and its implications in various diseases, including autoimmune disorders and cancer.
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IKK-ε Antibody (C-9) References:
- Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases. | Chariot, A., et al. 2002. J Biol Chem. 277: 37029-36. PMID: 12133833
- IKK-ε coordinates invasion and metastasis of ovarian cancer. | Hsu, S., et al. 2012. Cancer Res. 72: 5494-504. PMID: 22942254
- IκB kinase ε (IKKε): a therapeutic target in inflammation and cancer. | Verhelst, K., et al. 2013. Biochem Pharmacol. 85: 873-80. PMID: 23333767
- SPI-2/CrmA inhibits IFN-β induction by targeting TBK1/IKKε. | Qin, Y., et al. 2017. Sci Rep. 7: 10495. PMID: 28874755
- Roles for the IKK-Related Kinases TBK1 and IKKε in Cancer. | Durand, JK., et al. 2018. Cells. 7: PMID: 30223576
- PSMB1 Negatively Regulates the Innate Antiviral Immunity by Facilitating Degradation of IKK-ε. | Wu, F., et al. 2019. Viruses. 11: PMID: 30682859
- SAMHD1 impairs type I interferon induction through the MAVS, IKKε, and IRF7 signaling axis during viral infection. | Espada, CE., et al. 2023. J Biol Chem. 299: 104925. PMID: 37328105
- Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection. | Ullah, TR., et al. 2023. Nat Commun. 14: 5666. PMID: 37723181
- DLG1 promotes the antiviral innate immune response by inhibiting p62-mediated autophagic degradation of IKKε. | Chang, H., et al. 2023. J Virol. 97: e0150123. PMID: 37982618
- Viperin inhibits interferon-γ production to promote Mycobacterium tuberculosis survival by disrupting TBK1-IKKε-IRF3-axis and JAK-STAT signaling. | Liang, Y., et al. 2024. Inflamm Res. 73: 897-913. PMID: 38625657
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IKK-ε Antibody (C-9) | sc-365830 | 200 µg/ml | $322.00 | |||
IKK-ε (C-9) Neutralizing Peptide | sc-365830 P | 100 µg/0.5 ml | $69.00 |