IFN-γRβ Antibody (2 HUB 145): sc-53588

IFN-γRβ Antibody (2 HUB 145) is a hamster monoclonal IgG antibody that detects IFN-γRβ in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). IFN-γRβ, also known as the signal transducing component of the interferon-gamma receptor, plays a crucial role in mediating the biological effects of interferon-gamma, including antiviral and immunomodulatory responses. IFN-γRβ is primarily located on the cell surface, where IFN-γRβ forms a functional receptor complex with IFN-γRα. Both chains are essential for receptor′s ability to transduce signals that lead to the activation of genes involved in immune responses. IFN-γRβ interaction with Janus kinases (JAK1 and JAK2) upon ligand binding initiates a cascade of phosphorylation events, ultimately resulting in the activation of transcription factors such as Stat1. This process is vital for the regulation of immune responses and the maintenance of cellular homeostasis, making IFN-γRβ a significant target for research in immunology and therapeutic interventions. Anti-IFN-γRβ antibody (2 HUB 145) is an invaluable tool for scientists studying the intricate mechanisms of immune signaling and the role of interferon-gamma in various diseases.

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IFN-γRβ Antibody (2 HUB 145) References:

1. Complementation of a pathogenic IFNGR2 misfolding mutation with modifiers of N-glycosylation.  |  Vogt, G., et al. 2008. J Exp Med. 205: 1729-37. PMID: 18625743
2. The C-terminus of interferon gamma receptor beta chain (IFNgammaR2) has antiapoptotic activity as a Bax inhibitor.  |  Gomez, JA., et al. 2009. Cancer Biol Ther. 8: 1771-86. PMID: 19657228
3. Multiple cutaneous squamous cell carcinomas in a patient with interferon gamma receptor 2 (IFN gamma R2) deficiency.  |  Toyoda, H., et al. 2010. J Med Genet. 47: 631-4. PMID: 20587411
4. Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection.  |  Nalpas, B., et al. 2010. Gut. 59: 1120-6. PMID: 20587546
5. Haploinsufficiency at the human IFNGR2 locus contributes to mycobacterial disease.  |  Kong, XF., et al. 2013. Hum Mol Genet. 22: 769-81. PMID: 23161749
6. Interferon gamma receptor 2 gene variants are associated with liver fibrosis in the general population: the Rotterdam Study.  |  Plompen, EP., et al. 2015. Gut. 64: 692-4. PMID: 25301852
7. Genetic association of key Th1/Th2 pathway candidate genes, IRF2, IL6, IFNGR2, STAT4 and IL4RA, with atopic asthma in the Indian population.  |  Kumar, A., et al. 2015. J Hum Genet. 60: 443-8. PMID: 25994869
8. A digenic human immunodeficiency characterized by IFNAR1 and IFNGR2 mutations.  |  Hoyos-Bachiloglu, R., et al. 2017. J Clin Invest. 127: 4415-4420. PMID: 29106381
9. A Novel Splice Site Mutation in IFNGR2 in Patients With Primary Immunodeficiency Exhibiting Susceptibility to Mycobacterial Diseases.  |  Bandari, AK., et al. 2019. Front Immunol. 10: 1964. PMID: 31497017
10. Interferon-gamma receptor beta-chain expression and formation of alpha- and beta-chain complexes after receptor conjugation on human peripheral eosinophils.  |  Ishiharu, C., et al. 1998. Int Arch Allergy Immunol. 117 Suppl 1: 72-6. PMID: 9758903

The preferred IFN-γRβ antibody is IFN-γRβ Antibody (A-11): sc-377291.