IAA-94 (CAS 54197-31-8)

IAA-94 belongs to the class of indanyloxyacetic acid derivatives and is known for its unique property as a blocker of epithelial chloride channels. IAA-94 has been widely employed in scientific research to modulate the function of chloride channels and investigate their dynamics and physiological roles. Chloride channels are membrane proteins that play a role in regulating chloride ion flux across cell membranes. By selectively blocking these channels, IAA-94 allows researchers to study the function and properties of chloride channels in various biological systems. One of the significant scientific applications of IAA-94 is its use as a tool to probe the dynamics and function of chloride channels. By selectively inhibiting chloride channels, researchers can investigate the impact of altered chloride flux on cellular processes and gain insights into the physiological roles of these channels in different tissues and organs. Furthermore, the high affinity of IAA-94 for chloride channels has been exploited for the isolation and reconstitution of these proteins. The compound′s strong binding to chloride channels allows researchers to effectively isolate and study these channels in their native form or reconstitute them in artificial lipid bilayers. This enables a more detailed examination of their structure, function, and pharmacological properties. The mechanism of action of IAA-94 involves its binding to specific sites on epithelial chloride channels, leading to the inhibition of chloride ion transport across cell membranes. This selective blocking of chloride channels by IAA-94 interferes with their normal function, providing researchers with a means to investigate the physiological and pathological roles of chloride channels in various biological systems.