Hymeglusin CAS: 29066-42-0
MF: C18H28O5
MW: 324.4
An irreversible HMG-CoA synthase inhibitor.

Hymeglusin (CAS 29066-42-0)

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Synonym: 11-[3R-(hydroxymethyl)-4-oxo-2R-oxetanyl]-3,5,7R-trimethyl-2E,4E-undecadienoic acid
Application: An irreversible HMG-CoA synthase inhibitor
CAS Number: 29066-42-0
Purity: >95%
Molecular Weight: 324.4
Molecular Formula: C18H28O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Hymeglusin is a fungal β-lactone cell wall-targeting antibiotic that irreversibly inhibits cytosolic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase by covalently modifying the active Cys 129 residue of the enzyme. Studies show that hymeglusin can be inhibited by the (2R, 3R)-isomer of β-lactone trans-DU-6622 because this lactone binds to the same site on HMG-CoA synthase as hymeglusin. In addition, hymeglusin suppresses the translation of cWRA in Staphylococcus aureus, which codes for a polypepetide that responds to cell wall inhibition.


1. Tomoda, H., et al. 1999. Biochem. Biophys. Res. Commun. 265: 536-540. PMID: 10558904
2. Tomoda, H., et al. 2004. Biochim. Biophys. Acta. 1636: 22-28. PMID: 14984735
3. Balibar, C.J., et al. 2010. Microbiology. 156: 1372-1383. PMID: 20167623

Physical State :
Derived From :
Scopulariopsis sp. F-244.
Solubility :
Soluble in methanol, 100% ethanol, DMSO (0.90-1.10 mg/ml), and chloroform. Insoluble in water.
Storage :
Store at -20° C
Melting Point :
196.60° C (Predicted)
Boiling Point :
516.58° C at 760 mmHg (Predicted)
Density :
1.10 g/cm3 (Predicted)
Refractive Index :
n20D 1.51 (Predicted)
pK Values :
pKa: 4.98 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
C[[email protected]](CCCC[[email protected]@H]1[[email protected]](C(=O)O1)CO)C/C(=C/C(=C/C(=O)O)/C)/C

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Certificate of Analysis

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Hymeglusin  Product Citations

See how others have used Hymeglusin. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26698156  Stäubert, C. et al. 2016. Med. Oncol. 33: 6.

Citations 1 to 1 of 1 total
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