HYLS1 Antibody (F-12): sc-393492

HYLS1 Antibody (F-12) is a mouse monoclonal IgG3 kappa light chain antibody that detects HYLS1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). HYLS1 (F-12) antibody is available as a non-conjugated antibody. Hydrolethalus syndrome protein 1 (HYLS1) is a highly conserved protein crucial for cilia formation, essential for various cellular functions, including cell signaling and movement. Proper cilia formation is vital for normal embryonic development and organ function; disruptions in this process can lead to severe developmental disorders. Mutations in HYLS1 can cause hydrolethalus syndrome, a perinatal lethal condition characterized by significant malformations, including central nervous system anomalies such as hydrocephaly and absent midline structures, as well as micrognathia and polydactyly. HYLS1 is located on human chromosome 11, a region known for its density of gene and disease associations, which includes the Atm gene, important for regulating cell cycle arrest and apoptosis in response to DNA damage. Understanding HYLS1′s role in cilia formation and developmental disorders highlights its significance in both basic biology and clinical research.

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HYLS1 Antibody (F-12) References:

1. The 11q terminal deletion disorder: a prospective study of 110 cases.  |  Grossfeld, PD., et al. 2004. Am J Med Genet A. 129A: 51-61. PMID: 15266616
2. Hydrolethalus syndrome is caused by a missense mutation in a novel gene HYLS1.  |  Mee, L., et al. 2005. Hum Mol Genet. 14: 1475-88. PMID: 15843405
3. Human chromosome 11 DNA sequence and analysis including novel gene identification.  |  Taylor, TD., et al. 2006. Nature. 440: 497-500. PMID: 16554811
4. Phase I study of eptifibatide in patients with sickle cell anaemia.  |  Lee, SP., et al. 2007. Br J Haematol. 139: 612-20. PMID: 17916103
5. Wilms tumour: prognostic factors, staging, therapy and late effects.  |  Kaste, SC., et al. 2008. Pediatr Radiol. 38: 2-17. PMID: 18026723
6. Activation and regulation of ATM kinase activity in response to DNA double-strand breaks.  |  Lee, JH. and Paull, TT. 2007. Oncogene. 26: 7741-8. PMID: 18066086
7. Hydrolethalus syndrome: neuropathology of 21 cases confirmed by HYLS1 gene mutation analysis.  |  Paetau, A., et al. 2008. J Neuropathol Exp Neurol. 67: 750-62. PMID: 18648327
8. Unraveling the disease pathogenesis behind lethal hydrolethalus syndrome revealed multiple changes in molecular and cellular level.  |  Honkala, H., et al. 2009. Pathogenetics. 2: 2. PMID: 19400947
9. The hydrolethalus syndrome protein HYLS-1 links core centriole structure to cilia formation.  |  Dammermann, A., et al. 2009. Genes Dev. 23: 2046-59. PMID: 19656802

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HYLS1 Antibody (F-12) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-HYLS1 Antibody (F-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HYLS1 Antibody (F-12) Specifications

Alternate Product Name: HYLS1

Product Clone Name: F-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 38-57

Epitope Target: HYLS1

Epitope Species: human

Product Reactivity/Detection: HYLS1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for HYLS1 Antibody (F-12): P: Blocking Peptide