Molecular structure of Hydroxyguanidine hemisulfate, CAS Number: 6345-29-5
Hydroxyguanidine hemisulfate (CAS 6345-29-5)
Alternate Names:
Hydroxyguanidine Sulfate
Application:
Hydroxyguanidine hemisulfate is a structural analog of NG-hydroxy-L-arginine
CAS Number:
6345-29-5
Molecular Weight:
248.22
Molecular Formula:
C2H10N6O2•H2SO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Hydroxyguanidine hemisulfate is a structural analog of NG-hydroxy-L-arginine that potentiates and stabilizes the relaxant effect of nitric oxide (NO). It has been used in biochemistry, physiology, pharmacology experiments, and in drug development. Hydroxyguanidine hemisulfate has found application in the examination of protein, enzyme, and biomolecule structure and function. Moreover, it has been employed to investigate drug mechanisms and facilitate drug development. Furthermore, it has been utilized to explore the impacts of drugs on cellular, tissue, and organismal biochemistry and physiology. Studies have found that Hydroxyguanidine hemisulfate inhibits cell growth, cell death, and inflammation.
Hydroxyguanidine hemisulfate (CAS 6345-29-5) References
- Unusual oxidative chemistry of N(omega)-hydroxyarginine and N-hydroxyguanidine catalyzed at an engineered cavity in a heme peroxidase. | Hirst, J. and Goodin, DB. 2000. J Biol Chem. 275: 8582-91. PMID: 10722697
- Oxidations of N(omega)-hydroxyarginine analogues and various N-hydroxyguanidines by NO synthase II: key role of tetrahydrobiopterin in the reaction mechanism and substrate selectivity. | Moali, C., et al. 2001. Chem Res Toxicol. 14: 202-10. PMID: 11258969
- Potentiation of the vasorelaxant activity of nitric oxide by hydroxyguanidine: implications for the nature of endothelium-derived relaxing factor. | Zembowicz, A., et al. 1992. Br J Pharmacol. 107: 1001-7. PMID: 1281716
- Chemical oxidation of N-hydroxyguanidine compounds. Release of nitric oxide, nitroxyl and possible relationship to the mechanism of biological nitric oxide generation. | Fukuto, JM., et al. 1992. Biochem Pharmacol. 43: 607-13. PMID: 1540216
- Nitric oxide involvement in the toxicity of hydroxyguanidine in leukaemia HL60 cells. | Everett, SA., et al. 1996. Br J Cancer Suppl. 27: S172-6. PMID: 8763874
- Oxidation of N-hydroxyguanidine by nitric oxide and the possible generation of vasoactive species. | Yoo, J. and Fukuto, JM. 1995. Biochem Pharmacol. 50: 1995-2000. PMID: 8849325
- Oxidative denitrification of the antitumour drug hydroxyguanidine. | Everett, SA., et al. 1998. Free Radic Biol Med. 24: 1-10. PMID: 9436608
- Identification of an N-hydroxyguanidine reducing activity of xanthine oxidase. | Dambrova, M., et al. 1998. Eur J Biochem. 257: 178-84. PMID: 9799117
- Hydroxyguanidines inhibit peroxynitrite-induced oxidation. | Southan, GJ., et al. 1998. Free Radic Biol Med. 25: 914-25. PMID: 9840736
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hydroxyguanidine hemisulfate, 50 mg | sc-221734 | 50 mg | $193.00 |