HXK I Antibody (A-7): sc-271865

HXK I Antibody (A-7) is a mouse monoclonal IgG1 antibody that detects hexokinase I (HXK I) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HXK I is a crucial enzyme in glucose metabolism, catalyzing the phosphorylation of glucose to glucose-6-phosphate, which is the first step in the glycolytic pathway. This process is vital for cellular energy production and metabolic regulation, particularly in tissues with high energy demands such as the brain, heart, and skeletal muscles. Notably, HXK I is predominantly expressed in brain, kidney, and heart tissues, where HXK I plays a significant role in maintaining glucose homeostasis. HXK I activity is tightly regulated, and HXK I expression levels can influence insulin sensitivity and overall metabolic health. Anti-HXK I antibody (A-7) is an essential tool for researchers studying glucose metabolism and its implications in various diseases, including diabetes and cancer, providing insights into HXK I function and potential as a therapeutic target.

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HXK I Antibody (A-7) References:

1. Overexpression of Hexokinase 1 as a poor prognosticator in human colorectal cancer.  |  He, X., et al. 2016. Tumour Biol. 37: 3887-95. PMID: 26476538
2. Cytotoxic Activity of Boesenbergia rotunda Extracts against Nasopharyngeal Carcinoma Cells (HK1). Cardamonin, a Boesenbergia rotunda Constituent, Inhibits Growth and Migration of HK1 Cells by Inducing Caspase-Dependent Apoptosis and G2/M-Phase Arrest.  |  Break, MKB., et al. 2021. Nutr Cancer. 73: 473-483. PMID: 32270712
3. KLF2 mediates the suppressive effect of BDNF on diabetic intimal calcification by inhibiting HK1 induced endothelial-to-mesenchymal transition.  |  Wang, FF., et al. 2022. Cell Signal. 94: 110324. PMID: 35364229
4. Inhibiting mitochondrial inflammation through Drp1/HK1/NLRP3 pathway: A mechanism of alpinetin attenuated aging-associated cognitive impairment.  |  Chen, Y., et al. 2023. Phytother Res. 37: 2454-2471. PMID: 36772986
5. ErbB2-upregulated HK1 and HK2 promote breast cancer cell proliferation, migration and invasion.  |  Ma, X., et al. 2023. Med Oncol. 40: 154. PMID: 37079118
6. Mucosal recombinant BCG vaccine induces lung-resident memory macrophages and enhances trained immunity via mTORC2/HK1-mediated metabolic rewiring.  |  Peng, X., et al. 2024. J Biol Chem. 300: 105518. PMID: 38042489
7. DDX24 promotes tumor progression by mediating hexokinase-1 induced glycolysis in gastric cancer.  |  Ni, Y. and Zhuang, Z. 2024. Cell Signal. 114: 110995. PMID: 38043669
8. Hexokinase 1 and 2 mediates glucose utilization to regulate the synthesis of kappa casein via ribosome protein subunit 6 kinase 1 in bovine mammary epithelial cells.  |  Yang, T., et al. 2024. Anim Nutr. 16: 338-349. PMID: 38362515
9. Serum autoantibodies against hexokinase 1 manifest secondary to diabetic macular edema onset.  |  Šimčíková, D., et al. 2024. Diabetes Res Clin Pract. 212: 111721. PMID: 38821414
10. MiR-34a-HK1 signal axis retards bone marrow mesenchymal stem cell senescence via ameliorating glycolytic metabolism.  |  Sun, Y., et al. 2024. Stem Cell Res Ther. 15: 238. PMID: 39080798

The preferred HXK I antibody is HXK I Antibody (G-1): sc-46695.