HSV-1/2 Envelope Protein Antibody (0171): sc-58152

HSV-1/2 Envelope Protein Antibody (0171) is a mouse monoclonal IgG2a antibody that detects HSV-1/2 Envelope Protein of Herpes simplex virus types 1 and 2 by western blotting (WB) and immunofluorescence (IF). Anti-HSV-1/2 Envelope Protein antibody (0171) is available as a non-conjugated format. HSV envelope protein plays a crucial role in viral infection of host cells by mediating fusion of viral envelope with host cell membrane during viral entry. Glycoproteins embedded in viral envelope interact with specific receptors on host cell surfaces, enabling viral entry and infection establishment. Understanding HSV envelope protein function remains essential for developing therapeutic strategies, representing a potential target for antiviral drugs and vaccines against herpes simplex virus infections. HSV′s ability to establish lifelong latency in sensory ganglia, combined with envelope protein′s role in host cell recognition, highlights challenges in managing HSV infections, as viruses can evade immune systems and persist dormantly, causing recurrent outbreaks.

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HSV-1/2 Envelope Protein Antibody (0171) References:

1. Herpes simplex virus type 2 (HSV-2) infection in women attending an antenatal clinic in the South Pacific island nation of Vanuatu.  |  Haddow, LJ., et al. 2007. Sex Transm Dis. 34: 258-61. PMID: 16940899
2. The microenvironment of vulvar skin in women with symptomatic and asymptomatic herpes simplex virus type 2 (HSV-2) infection.  |  Löwhagen, GB., et al. 2006. J Eur Acad Dermatol Venereol. 20: 1086-9. PMID: 16987263
3. Development and validation of a capillary electrophoresis method for the characterization of herpes simplex virus type 1 (HSV-1) thymidine kinase substrates and inhibitors.  |  Iqbal, J., et al. 2007. J Chromatogr B Analyt Technol Biomed Life Sci. 846: 281-90. PMID: 17023224
4. The HSV-2 protein ICP10PK prevents neuronal apoptosis and loss of function in an in vivo model of neurodegeneration associated with glutamate excitotoxicity.  |  Golembewski, EK., et al. 2007. Exp Neurol. 203: 381-93. PMID: 17046754
5. Association between HSV-2 and HIV-1 viral load in semen, cervico-vaginal secretions and genital ulcers of Thai men and women.  |  Chu, K., et al. 2006. Int J STD AIDS. 17: 681-6. PMID: 17059638
6. HSV infection and immunosuppression.  |  Sindhi, R. 2006. Liver Transpl. 12: 1906-7. PMID: 17133569
7. Sulfasalazine unveils a contact-independent HSV-TK/ganciclovir gene therapy bystander effect in malignant gliomas.  |  Robe, PA., et al. 2007. Int J Oncol. 30: 283-90. PMID: 17143539
8. Herpes simplex virus type 2 (HSV-2) establishes latent infection in a different population of ganglionic neurons than HSV-1: role of latency-associated transcripts.  |  Margolis, TP., et al. 2007. J Virol. 81: 1872-8. PMID: 17151134
9. HSV-2- and HIV-1- permissive cell lines co-infected by HSV-2 and HIV-1 co-replicate HSV-2 and HIV-1 without production of HSV-2/HIV-1 pseudotype particles.  |  Legoff, J., et al. 2007. Virol J. 4: 2. PMID: 17207276
10. Escherichia coli-derived envelope protein gD but not gC antigens of herpes simplex virus protect mice against a lethal challenge with HSV-1 and HSV-2.  |  Bröker, M., et al. 1990. Med Microbiol Immunol. 179: 145-59. PMID: 2169577
11. Targeting a conserved pocket (n-octyl-β-D-glucoside) on the dengue virus envelope protein by small bioactive molecule inhibitors.  |  Naresh, P., et al. 2022. J Biomol Struct Dyn. 40: 4866-4878. PMID: 33345726
12. Enhancement of HSV-1 cell-free virion release by the envelope protein gC.  |  Frost, TC., et al. 2024. Virology. 596: 110120. PMID: 38805801

The preferred HSV-1 antibody is HSV-1 Antibody (20.7.1): sc-57863.