HSPB7 Antibody (F-4): sc-393739

HSPB7 Antibody (F-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects HSPB7 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-HSPB7 antibody (F-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HSPB7, also known as cardiovascular heat shock protein or heat shock protein beta-7, is a member of the small heat shock protein family, which plays a crucial role in cellular stress responses. HSPB7 is predominantly expressed in the cytoplasm and is particularly abundant in heart and skeletal muscle tissues. This localization enables HSPB7 to interact with denatured proteins and prevent aggregation, maintaining cellular protein homeostasis during stress conditions. HSPB7 expression significantly increases in response to muscle fiber transformation and in various muscular dystrophies, suggesting potential as a therapeutic target for age-related muscle wasting and other muscle-related disorders. Research using HSPB7 (F-4) monoclonal antibody can provide valuable insights into muscle health and disease.

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HSPB7 Antibody (F-4) References:

1. Identification and characterization of cvHsp. A novel human small stress protein selectively expressed in cardiovascular and insulin-sensitive tissues.  |  Krief, S., et al. 1999. J Biol Chem. 274: 36592-600. PMID: 10593960
2. The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10.  |  Kappé, G., et al. 2003. Cell Stress Chaperones. 8: 53-61. PMID: 12820654
3. The sperm outer dense fiber protein is the 10th member of the superfamily of mammalian small stress proteins.  |  Fontaine, JM., et al. 2003. Cell Stress Chaperones. 8: 62-9. PMID: 12820655
4. Interaction of human HSP22 (HSPB8) with other small heat shock proteins.  |  Sun, X., et al. 2004. J Biol Chem. 279: 2394-402. PMID: 14594798
5. Interactions of HSP22 (HSPB8) with HSP20, alphaB-crystallin, and HSPB3.  |  Fontaine, JM., et al. 2005. Biochem Biophys Res Commun. 337: 1006-11. PMID: 16225851
6. Proteome analysis of the dystrophin-deficient MDX diaphragm reveals a drastic increase in the heat shock protein cvHSP.  |  Doran, P., et al. 2006. Proteomics. 6: 4610-21. PMID: 16835851
7. Proteomic profiling of pathological and aged skeletal muscle fibres by peptide mass fingerprinting (Review).  |  Doran, P., et al. 2007. Int J Mol Med. 19: 547-64. PMID: 17334630
8. Aging skeletal muscle shows a drastic increase in the small heat shock proteins alphaB-crystallin/HspB5 and cvHsp/HspB7.  |  Doran, P., et al. 2007. Eur J Cell Biol. 86: 629-40. PMID: 17761354

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HSPB7 Antibody (F-4) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-HSPB7 Antibody (F-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HSPB7 Antibody (F-4) Specifications

Alternate Product Name: HSPB7

Product Clone Name: F-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-170

Epitope Target: HSPB7

Epitope Species: human

Product Reactivity/Detection: HSPB7

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for HSPB7 Antibody (F-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin