HPPD Antibody (F-5): sc-271672

HPPD Antibody (F-5) is a mouse monoclonal IgG2a antibody that detects HPPD in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HPPD, or 4-hydroxyphenylpyruvate dioxygenase, is a crucial 393 amino acid protein that plays a significant role in the degradation of amino acids, specifically in the conversion of L-phenylalanine to fumarate and acetoacetic acid, a process vital for maintaining metabolic balance. HPPD exists as a homodimer and utilizes zinc as a cofactor, highlighting the importance of metal ions in enzymatic reactions. Defects in the gene encoding HPPD can lead to serious metabolic disorders such as tyrosinemia type 3 and hawkinsinuria, which manifest in various symptoms including cognitive impairments and metabolic abnormalities. The gene for HPPD is located on human chromosome 12, a region that encodes over 1,100 genes and constitutes approximately 4.5% of the human genome, underscoring the complexity and interconnectivity of genetic functions within this chromosomal area. Anti-HPPD antibody (F-5) is an essential tool for researchers studying these metabolic pathways and their implications in human health.

The preferred HPPD antibody is HPPD Antibody (B-11): sc-390279.