HoxC10 Antibody (3F2): sc-517164
- HoxC10 Antibody (3F2) is a mouse monoclonal IgG2a κ HoxC10 antibody, cited in 1 publications, provided at 100 µg/ml
- raised against amino acids 158-257 representing partial length HoxC10 of human origin
- recommended for detection of HoxC10 of human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HoxC10 Antibody (3F2). This work is in progress.
HoxC10 Antibody (3F2) is a mouse monoclonal IgG2a kappa light chain antibody that detects HoxC10 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-HoxC10 antibody (3F2) is available as the non-conjugated format. HoxC10 is a crucial homeoprotein that plays a significant role in regulating gene expression during development and cellular differentiation. HoxC10 is primarily located in the nucleus, where HoxC10 binds to specific DNA sequences to modulate transcription of target genes involved in morphogenesis and patterning along the anterior-posterior axis. Nuclear localization allows HoxC10 to exert influence on developmental processes and maintain proper cellular functions. HoxC10 oscillates in abundance throughout the cell cycle, being targeted for degradation early in mitosis via the ubiquitin-dependent proteasome pathway, which underscores HoxC10′s importance in linking developmental regulation with cell cycle control. HoxC10′s ability to interact with various proteins involved in these processes highlights potential implications in conditions such as leukemias and hereditary malformations, making HoxC10 a valuable target for research in developmental biology and cancer studies.
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HoxC10 Antibody (3F2) References:
- Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression. | Gabellini, D., et al. 2003. EMBO J. 22: 3715-24. PMID: 12853486
- Enhancer timing of Hox gene expression: deletion of the endogenous Hoxc8 early enhancer. | Juan, AH. and Ruddle, FH. 2003. Development. 130: 4823-34. PMID: 12917291
- HOXC and HOXD gene expression in human endometrium: lack of redundancy with HOXA paralogs. | Akbas, GE. and Taylor, HS. 2004. Biol Reprod. 70: 39-45. PMID: 12954737
- Aberrant HOXC expression accompanies the malignant phenotype in human prostate. | Miller, GJ., et al. 2003. Cancer Res. 63: 5879-88. PMID: 14522913
- The spatial restrictions of 5'HoxC genes expression are maintained in adult newt spinal cord. | Nicolas, S., et al. 2003. Biol Cell. 95: 589-94. PMID: 14720461
- Loss of HOXC6 expression induces apoptosis in prostate cancer cells. | Ramachandran, S., et al. 2005. Oncogene. 24: 188-98. PMID: 15637592
- Expression of 11 HOX genes is deregulated in esophageal squamous cell carcinoma. | Chen, KN., et al. 2005. Clin Cancer Res. 11: 1044-9. PMID: 15709170
- Gene expression profiling reveals novel regulation by bisphenol-A in estrogen receptor-alpha-positive human cells. | Singleton, DW., et al. 2006. Environ Res. 100: 86-92. PMID: 16029874
- Analysis of single nucleotide polymorphisms and haplotypes in HOXC gene cluster within susceptible region 12q13 of simple congenital heart disease. | Gong, LG., et al. 2005. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 22: 497-501. PMID: 16215934
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HoxC10 Antibody (3F2) | sc-517164 | 100 µg/ml | $322.00 |