Molecular structure of Hh/Gli Antagonist, GANT58, CAS Number: 64048-12-0
Hh/Gli Antagonist, GANT58 (CAS 64048-12-0)
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Application:
Hh/Gli Antagonist, GANT58 is a cell-permeable tetrapyridinylthiophene
CAS Number:
64048-12-0
Molecular Weight:
392.5
Molecular Formula:
C24H16N4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Hh/Gli Antagonist, GANT58 is a cell-permeable tetrapyridinylthiophene compound that acts as downstream Hedgehog (Hh) pathway blocker and targets Gli-mediated gene transactivation (IC50 ~ 5 7mu;M in SAG-stimulated Shh-L2 cells). Hh/Gli Antagonist, GANT58 has beem shown to reduce cellular mRNA levels of Hh target genes, Gli1, Hip1,& Ptch, and inhibit Gli-dependent tumor growth in vitro. Its action appears to be Hh pathway-selective, downstream of Smo and Sufu, but does not seem to interfere with Gli DNA binding.
Hh/Gli Antagonist, GANT58 (CAS 64048-12-0) References
Lauth, M., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8455.Inhibitor of:
hedgehog.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hh/Gli Antagonist, GANT58, 5 mg | sc-221723 | 5 mg | $159.00 |