Date published: 2026-5-9

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Hexobendine Dihydrochloride (CAS 50-62-4)

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Alternate Names:
3,4,5-Trimethoxybenzoic Acid 1,2-Ethanediylbis[(methylimino)-3,1-propanediyl] Ester Dihydrochloride; 3,3′-[Ethylenebis(methylimino)]di-1-propanol Bis(3,4,5-trimethoxybenzoate) (Ester) Dihydrochloride; Andiamine; Hexobendin Hydrochloride; Reoxyl
CAS Number:
50-62-4
Molecular Weight:
665.6
Molecular Formula:
C30H46Cl2N2O10
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Hexobendine dihydrochloride is a compound that functions as a calcium channel blocker. It acts by inhibiting the influx of calcium ions into cardiac and smooth muscle cells, leading to relaxation of the muscles. Hexobendine Dihydrochloride targets L-type calcium channels, which are responsible for regulating the flow of calcium ions into the cells. By blocking these channels, hexobendine dihydrochloride reduces the contractility of the heart and smooth muscle, leading to vasodilation and decreased cardiac workload. This mechanism of action may be a useful for studying the role of calcium channels in cardiac and smooth muscle function. Its ability to modulate calcium ion influx provides insights into the physiological processes involved in muscle contraction and relaxation. Hexobendine dihydrochloride′s mechanism of action as a calcium channel blocker contributes to the understanding of cellular and molecular mechanisms underlying muscle function in experimental applications.


Hexobendine Dihydrochloride (CAS 50-62-4) References

  1. Dissimilarities between benzodiazepine-binding sites and adenosine uptake sites in astrocytes and neurons in primary cultures.  |  Bender, AS. and Hertz, L. 1987. J Neurosci Res. 17: 154-61. PMID: 3035203
  2. Do benzodiazepines bind at adenosine uptake sites in CNS?  |  Wu, PH., et al. 1981. Life Sci. 28: 1023-31. PMID: 6111732
  3. The rapid uptake and release of [3H]adenosine by rat cerebral cortical synaptosomes.  |  Bender, AS., et al. 1981. J Neurochem. 36: 651-60. PMID: 7463081

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Hexobendine Dihydrochloride, 25 mg

sc-491144
25 mg
$311.00