Date published: 2025-11-30

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Herbicidin A (CAS 55353-31-6)

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Application:
Herbicidin A is a chemical with antibacterial and herbicidal activity
CAS Number:
55353-31-6
Molecular Weight:
551.50
Molecular Formula:
C23H29N5O11
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Herbicidin A is a complex nucleoside antibiotic derived from certain *Streptomyces* species, notable for its unique structure that combines a furanosyl nucleoside with an unsaturated fatty acid chain. It operates primarily by inhibiting RNA polymerase, an essential enzyme for RNA synthesis in many organisms, thereby blocking transcription processes and leading to cell death in targeted cells. This mechanism has made Herbicidin A a valuable tool in microbiological research, particularly in studying the complex interactions between antibiotics and their target proteins within bacterial cells. Additionally, its herbicidal properties are of significant interest in agricultural research, where Herbicidin A is explored for its potential to develop new herbicide formulations that can selectively inhibit crucial biological pathways in weeds, potentially offering a novel approach to manage herbicide resistance in crops. This dual functionality not only underscores its utility in understanding bacterial transcription and enzyme inhibition but also in advancing agricultural practices through the development of targeted weed management strategies.


Herbicidin A (CAS 55353-31-6) References

  1. Isolation and characterization of culturable endophytic actinobacteria associated with Artemisia annua L.  |  Li, J., et al. 2012. Antonie Van Leeuwenhoek. 101: 515-27. PMID: 22038129
  2. Wollamides: antimycobacterial cyclic hexapeptides from an Australian soil Streptomyces.  |  Khalil, ZG., et al. 2014. Org Lett. 16: 5120-3. PMID: 25229313
  3. 8'-epimer of herbicidin F and its congeners from Streptomyces sp. YIM 66142.  |  Zhang, JC., et al. 2017. J Antibiot (Tokyo). 70: 313-316. PMID: 27876750
  4. Optimization of Herbicidin A Production in Submerged Culture of Streptomyces scopuliridis M40.  |  Ha, S., et al. 2017. J Microbiol Biotechnol. 27: 947-955. PMID: 28237998
  5. Identification and Interrogation of the Herbicidin Biosynthetic Gene Cluster: First Insight into the Biosynthesis of a Rare Undecose Nucleoside Antibiotic.  |  Lin, GM., et al. 2017. J Am Chem Soc. 139: 16450-16453. PMID: 29111702
  6. Herbicidins from Streptomyces sp. CB01388 Showing Anti- Cryptosporidium Activity.  |  Chen, JJ., et al. 2018. J Nat Prod. 81: 791-797. PMID: 29469575
  7. Elucidation of the Herbicidin Tailoring Pathway Offers Insights into Its Structural Diversity.  |  Pan, HX., et al. 2019. Org Lett. 21: 1374-1378. PMID: 30763106
  8. Terminal steps in the biosynthesis of herbicidins, nucleoside antibiotics.  |  Yoshikawa, H., et al. 1983. J Antibiot (Tokyo). 36: 30-5. PMID: 6678913
  9. Herbicidins A and B, two new antibiotics with herbicidal activity. I. Producing organism and biological activities.  |  Arai, M., et al. 1976. J Antibiot (Tokyo). 29: 863-9. PMID: 993127
  10. Herbicidins A and B, two new antibiotics with herbicidal activity II. Fermentation, isolation and physico-chemical characterization.  |  Haneishi, T., et al. 1976. J Antibiot (Tokyo). 29: 870-5. PMID: 993128

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Herbicidin A, 1 mg

sc-397308
1 mg
$295.00