H2-K^k Antibody (36-7-5): sc-52551

H2-Kk Antibody (36-7-5) is a mouse monoclonal IgG2a antibody that detects H2-Kk in mouse samples through immunofluorescence (IF) and flow cytometry (FCM) applications. H2-Kk is a crucial component of the major histocompatibility complex (MHC) class I molecules, which play a vital role in the immune response by presenting foreign peptides to cytotoxic T lymphocytes (CTLs). H2-Kk (36-7-5) antibody enables researchers to study proper functioning of H2-Kk, which is essential for CTL activation and elimination of infected or malignant cells. Located on the surface of cells, H2-Kk binds to peptides derived from intracellular proteins, allowing the immune system to monitor cellular health and respond to pathogens effectively. The structure of H2-Kk, consisting of a heavy chain and the non-covalently associated β-2-Microglobulin, is critical for antigen presentation and T cell receptor interactions. This interaction is fundamental for initiating adaptive immune responses, making H2-Kk a key player in maintaining immune surveillance and tolerance. Anti-H2-Kk antibody (36-7-5) serves as an invaluable tool for researchers studying immune responses, cellular interactions, and the role of MHC molecules in various biological processes.

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H2-K^k Antibody (36-7-5) References:

1. Jun oncoproteins do not function as primary transcription factors for the mouse major histocompatibility complex class I H-2 genes in fibroblasts.  |  Hatina, J. and Reischig, J. 2003. Eur J Immunogenet. 30: 253-7. PMID: 12919286
2. Major histocompatibility complex antigens in v-Ki-ras transformed cells: the different antigens are expressed and induced by interferons independently of one another and of the anti-viral state.  |  Morris, AG. 1990. Immunology. 71: 224-9. PMID: 1699881
3. Reduced tumorigenicity of murine tumor cells secreting gamma-interferon is due to nonspecific host responses and is unrelated to class I major histocompatibility complex expression.  |  Esumi, N., et al. 1991. Cancer Res. 51: 1185-9. PMID: 1900037
4. Identification of glycoproteins carrying a target glycan-motif by liquid chromatography/multiple-stage mass spectrometry: identification of Lewis x-conjugated glycoproteins in mouse kidney.  |  Hashii, N., et al. 2009. J Proteome Res. 8: 3415-29. PMID: 19453144
5. Antigen-specific recognition is critical for the function of regulatory CD8(+)CD28(-) T cells.  |  Renner, P., et al. 2010. Transpl Immunol. 22: 144-9. PMID: 19840851
6. A minigene DNA vaccine encoding peptide epitopes derived from Galectin-1 has protective antitumoral effects in a model of neuroblastoma.  |  Liebscher, L., et al. 2021. Cancer Lett. 509: 105-114. PMID: 33848518
7. Purification of the H-2Kk molecule of the murine major histocompatibility complex.  |  Herrmann, SH. and Mescher, MF. 1979. J Biol Chem. 254: 8713-6. PMID: 479148
8. In vivo phenotypic characteristics of AKR T-cell lymphomas with different leukemic potential: possible role of alpha 4 beta 7 integrin in the progression towards the leukemic phenotype.  |  Dolcetti, R., et al. 1994. Int J Cancer. 56: 560-7. PMID: 8112892
9. An acidic modification of the cytoplasmic domain contributes to the charge heterogeneity of the MHC class I antigens.  |  Balomenos, D. and Poretz, RD. 1998. Immunogenetics. 47: 381-9. PMID: 9510556
10. Glycan-regulated antigen processing of a protein in the endoplasmic reticulum can uncover cryptic cytotoxic T cell epitopes.  |  Wood, P. and Elliott, T. 1998. J Exp Med. 188: 773-8. PMID: 9705959

The preferred H2-K^k antibody is H2-K^k Antibody (AF3-12.1): sc-53851.