Date published: 2026-5-22

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H-L-Bpa-OH (CAS 104504-45-2)

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Alternate Names:
4-Benzoyl-L-phenylalanine
CAS Number:
104504-45-2
Molecular Weight:
269.29
Molecular Formula:
C16H15NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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H-L-Bpa-OH is a photoreactive unnatural amino acid. When incorporated into ion channels and transporter proteins, H-L-Bpa-OH acts as a photo cross-linking probe. H-L-Bpa-OH has also been incorporated into G protein-coupled receptors (GPCRs) to identify potential ligand binding sites.


H-L-Bpa-OH (CAS 104504-45-2) References

  1. Cell surface and substrate distribution of the 67-kDa laminin-binding protein determined by using a ligand photoaffinity probe.  |  Starkey, JR., et al. 1999. Cytometry. 35: 37-47. PMID: 10554179
  2. A concise synthesis of photoactivatable 4-aroyl-L-phenylalanines.  |  Morera, E. and Ortar, G. 2000. Bioorg Med Chem Lett. 10: 1815-8. PMID: 10969975
  3. Identification of a contact region between the tridecapeptide alpha-factor mating pheromone of Saccharomyces cerevisiae and its G protein-coupled receptor by photoaffinity labeling.  |  Henry, LK., et al. 2002. Biochemistry. 41: 6128-39. PMID: 11994008
  4. The action of TNFalpha and TGFbeta include specific alterations of the glycosylation of bovine and human chondrocytes.  |  Yang, X., et al. 2007. Biochim Biophys Acta. 1773: 264-72. PMID: 17079030
  5. Distinct metabolites for photoreactive L-phenylalanine derivatives in Klebsiella sp. CK6 isolated from rhizosphere of a wild dipterocarp sapling.  |  Wang, L., et al. 2013. Molecules. 18: 8393-401. PMID: 23863777
  6. The host antimicrobial peptide Bac71-35 binds to bacterial ribosomal proteins and inhibits protein synthesis.  |  Mardirossian, M., et al. 2014. Chem Biol. 21: 1639-47. PMID: 25455857
  7. Unnatural amino acid mutagenesis-based enzyme engineering.  |  Ravikumar, Y., et al. 2015. Trends Biotechnol. 33: 462-70. PMID: 26088007
  8. Important Late-Stage Symbiotic Role of the Sinorhizobium meliloti Exopolysaccharide Succinoglycan.  |  Arnold, MFF., et al. 2018. J Bacteriol. 200: PMID: 29632097
  9. Increased gene translation stringency in mammalian cells by nonsense suppression at multiple permissive sites with a single noncanonical amino acid.  |  Kadunc, L., et al. 2020. FEBS Lett. 594: 2452-2461. PMID: 32401336
  10. Engineering an acetyllysine reader with a photocrosslinking amino acid for interactome profiling.  |  Roy, A., et al. 2021. Chem Commun (Camb). 57: 9866-9869. PMID: 34490864
  11. High-throughput characterization of photocrosslinker-bearing ion channel variants to map residues critical for function and pharmacology.  |  Braun, N., et al. 2021. PLoS Biol. 19: e3001321. PMID: 34491979
  12. Amber Suppression Technology for Mapping Site-specific Viral-host Protein Interactions in Mammalian Cells.  |  Isa, NF., et al. 2022. Bio Protoc. 12: e4315. PMID: 35284605
  13. Pinpointing the interaction site between semaphorin-3A and its inhibitory peptide.  |  Kretschmer, K., et al. 2023. J Pept Sci. 29: e3460. PMID: 36285908

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

H-L-Bpa-OH, 1 g

sc-285965
1 g
$148.00

H-L-Bpa-OH, 5 g

sc-285965A
5 g
$547.00