Date published: 2026-4-24

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Gly-Phe-pNA (CAS 21027-72-5)

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Alternate Names:
Glycyl-L-phenylalanine p-nitroanilide
CAS Number:
21027-72-5
Molecular Weight:
342.35
Molecular Formula:
C17H18N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Gly-Phe-pNA is a dipeptide formulated from the amino acids glycine and phenylalanine, enhanced with a norvaline side chain. This compound, created synthetically, sparks interest for its observed cellular protective effect in lab settings and its use in studies exploring the impact of oxidative stress on cells. Additionally, it has been employed in research scrutinizing the impact of inflammation on cells, as well as the influence of peptides on the immune system. The specific mechanism of H-Gly-Phe-Pna′s action remains somewhat elusive. It′s postulated that the peptide could function as an antioxidant and anti-inflammatory agent, possibly scavenging free radicals and curtailing inflammation by limiting the release of pro-inflammatory cytokines. There′s also speculation that the peptide might shelter cells by adjusting the activity of certain enzymes.


Gly-Phe-pNA (CAS 21027-72-5) References

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  2. Identification of the catalytic triad of family S46 exopeptidases, closely related to clan PA endopeptidases.  |  Suzuki, Y., et al. 2014. Sci Rep. 4: 4292. PMID: 24598890
  3. Crystallization and preliminary X-ray crystallographic studies of dipeptidyl aminopeptidase BII from Pseudoxanthomonas mexicana WO24.  |  Sakamoto, Y., et al. 2014. Acta Crystallogr F Struct Biol Commun. 70: 221-4. PMID: 24637761
  4. S46 peptidases are the first exopeptidases to be members of clan PA.  |  Sakamoto, Y., et al. 2014. Sci Rep. 4: 4977. PMID: 24827749
  5. Rhipicephalus microplus and Ixodes ovatus cystatins in tick blood digestion and evasion of host immune response.  |  Parizi, LF., et al. 2015. Parasit Vectors. 8: 122. PMID: 25889092
  6. Structural and mutational analyses of dipeptidyl peptidase 11 from Porphyromonas gingivalis reveal the molecular basis for strict substrate specificity.  |  Sakamoto, Y., et al. 2015. Sci Rep. 5: 11151. PMID: 26057589
  7. Specificity of peptidases secreted by filamentous fungi.  |  Hamin Neto, YAA., et al. 2018. Bioengineered. 9: 30-37. PMID: 28857638
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Gly-Phe-pNA, 100 mg

sc-472613
100 mg
$334.00