Molecular structure of Gentamicin C1a, CAS Number: 26098-04-4
Gentamicin C1a (CAS 26098-04-4)
Alternate Names:
Gentamicin C
Application:
Gentamicin C1a is An antibacterial mixture preparation
CAS Number:
26098-04-4
Purity:
>95%
Molecular Weight:
449.50
Molecular Formula:
C19H39N5O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Gentamicin C1a is an antibacterial consisting of 3 closely related components (gentamicins C1, C2 and C1a). Also consists of a slightly different component of Gentamicin A and shares similarities to Kanamycin C. The structural analysis of this compound revealed that it is a semisynthetic gentamicin analog. It is used to treat a variety of bacterial infections, including those caused by Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae.
Gentamicin C1a (CAS 26098-04-4) References
- An isocratic separation of underivatized gentamicin components, 1H NMR assignment and protonation pattern. | Lesniak, W., et al. 2003. Carbohydr Res. 338: 2853-62. PMID: 14667706
- Characterization of the enzyme aac(3)-Id in a clinical isolate of Salmonella enterica serovar Haifa causing traveler's diarrhea. | Cabrera, R., et al. 2009. Enferm Infecc Microbiol Clin. 27: 453-6. PMID: 19403206
- Isolation and structure characterization of related impurities in etimicin sulfate by LC/ESI-MS(n) and NMR. | Wang, H., et al. 2011. J Pharm Biomed Anal. 55: 902-7. PMID: 21444173
- Preparative purification of gentamicin components using high-speed counter-current chromatography coupled with electrospray mass spectrometry. | Inoue, K., et al. 2011. J Sep Sci. 34: 1484-8. PMID: 21548130
- Construction of a gentamicin C1a-overproducing strain of Micromonospora purpurea by inactivation of the gacD gene. | Li, D., et al. 2013. Microbiol Res. 168: 263-7. PMID: 23305768
- Highly selective separation of aminoglycoside antibiotics on a zwitterionic Click TE-Cys column. | Wei, J., et al. 2014. J Sep Sci. 37: 1781-7. PMID: 24798626
- Biosynthesis of Epimers C2 and C2a in the Gentamicin C Complex. | Gu, Y., et al. 2015. Chembiochem. 16: 1933-1942. PMID: 26083124
- Improving gentamicin B and gentamicin C1a production by engineering the glycosyltransferases that transfer primary metabolites into secondary metabolites biosynthesis. | Wu, Z., et al. 2017. Microbiol Res. 203: 40-46. PMID: 28754206
- Exclusive Production of Gentamicin C1a from Micromonospora purpurea by Metabolic Engineering. | Wei, Z., et al. 2019. Antibiotics (Basel). 8: PMID: 31847403
- The bifunctional enzyme, GenB4, catalyzes the last step of gentamicin 3',4'-di-deoxygenation via reduction and transamination activities. | Chen, X., et al. 2020. Microb Cell Fact. 19: 62. PMID: 32156271
- Metabolomics of extracellular compounds and parasitic enzymes of Beauveria bassiana associated with biological control of whiteflies (Bemisia tabaci). | Bhadani, RV., et al. 2021. Pestic Biochem Physiol. 176: 104877. PMID: 34119221
- Engineering the methyltransferase through inactivation of the genK and genL leads to a significant increase of gentamicin C1a production in an industrial strain of Micromonospora echinospora 49-92S. | Xu, F., et al. 2022. Bioprocess Biosyst Eng. 45: 1693-1703. PMID: 36029348
- Synthesis of Gentamicin Minor Components: Gentamicin C1a and Gentamicin C2b. | Jana, S. and Crich, D. 2022. Org Lett. 24: 8564-8567. PMID: 36375034
- Forensic investigation of gentamicin sulfates by anion-exchange ion chromatography with pulsed electrochemical detection. | Kaine, LA. and Wolnik, KA. 1994. J Chromatogr A. 674: 255-61. PMID: 8075773
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gentamicin C1a, 5 mg | sc-207712A | 5 mg | $490.00 | |||
Gentamicin C1a, 10 mg | sc-207712 | 10 mg | $760.00 | |||
Gentamicin C1a, 25 mg | sc-207712B | 25 mg | $1428.00 | |||
Gentamicin C1a, 50 mg | sc-207712C | 50 mg | $2244.00 |