GAP1^m Antibody (15): sc-135916

GAP1m Antibody (15) is a mouse monoclonal IgG1 kappa light chain antibody that detects GAP1m protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-GAP1m antibody (15) is available as the non-conjugated format. GAP1m protein plays a crucial role in regulating the activity of Ras p21, a key player in cell signaling pathways that control cell growth and differentiation. By facilitating the hydrolysis of GTP bound to Ras p21, GAP1m enhances the conversion of Ras to its inactive GDP-bound form, thereby acting as a critical regulator of cellular signaling. This function is particularly important in preventing uncontrolled cell proliferation, which can lead to cancer. GAP1m is predominantly expressed in the brain, placenta, and kidney, highlighting its significance in various physiological processes. GAP1m contains a GAP catalytic domain, a phospholipid-binding region, and a domain homologous to a unique region of Bruton′s tyrosine kinase (Btk), which underscores its multifaceted role in cellular signaling and interaction with other proteins.

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GAP1^m Antibody (15) References:

1. Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleus.  |  Settleman, J., et al. 1992. Cell. 69: 539-49. PMID: 1581965
2. The GTPase superfamily: a conserved switch for diverse cell functions.  |  Bourne, HR., et al. 1990. Nature. 348: 125-32. PMID: 2122258
3. A guide to low molecular weight GTPases.  |  Sanders, DA. 1990. Cell Growth Differ. 1: 251-8. PMID: 2150754
4. A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants.  |  Trahey, M. and McCormick, F. 1987. Science. 238: 542-5. PMID: 2821624
5. ras genes.  |  Barbacid, M. 1987. Annu Rev Biochem. 56: 779-827. PMID: 3304147
6. A novel mammalian Ras GTPase-activating protein which has phospholipid-binding and Btk homology regions.  |  Maekawa, M., et al. 1994. Mol Cell Biol. 14: 6879-85. PMID: 7935405

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GAP1^m Antibody (15) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-GAP1^m Antibody (15) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GAP1^m Antibody (15) Specifications

Alternate Product Name: GAP1m

Product Clone Name: 15

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 20-200

Epitope Target: GAP1^m

Epitope Species: rat

Product Reactivity/Detection: GAP1^m

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for GAP1^m Antibody (15): N/A