GABA T-3 Antibody (G-6): sc-376001
- GABA T-3 Antibody (G-6) is a mouse monoclonal IgG2b κ GABA T-3 antibody, cited in 5 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 601-625 at the C-terminus of GABA T-3 of rat origin
- GABA T-3 Antibody (G-6) is recommended for detection of GABA T-3 of mouse and rat origin by WB, IP, IF, IHC(P) and ELISA
- Anti-GABA T-3 Antibody (G-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GABA T-3 Antibody (G-6). This work is in progress.
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GABA T-3 Antibody (G-6) is a mouse monoclonal IgG2b kappa light chain antibody that detects GABA T-3 of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). GABA T-3 (G-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GABA T-3, also known as GAT-3, is a critical component of the GABAergic system, functioning primarily as a high-affinity transporter that regulates gamma-aminobutyric acid (GABA) levels in the synaptic cleft. GABA T-3 is predominantly located in the brain, particularly in glial cells, where GABA T-3 plays a vital role in terminating GABA′s inhibitory action by facilitating reuptake into presynaptic terminals. Efficient recycling of GABA is essential for maintaining the balance of excitatory and inhibitory signals in the central nervous system, which is crucial for normal neuronal function and preventing excitotoxicity. GABA T-3′s ability to modulate GABA levels underscores GABA T-3′s importance in various neurological processes and potential implications in disorders characterized by GABA dysregulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GABA T-3 Antibody (G-6) References:
- Differential expression of the GABA transporters GAT-1 and GAT-3 in brains of rats, cats, monkeys and humans. | Pow, DV., et al. 2005. Cell Tissue Res. 320: 379-92. PMID: 15821932
- GABAergic modulation of the activity of globus pallidus neurons in primates: in vivo analysis of the functions of GABA receptors and GABA transporters. | Galvan, A., et al. 2005. J Neurophysiol. 94: 990-1000. PMID: 15829599
- Neuronal localization of the GABA transporter GAT-3 in human cerebral cortex: a procedural artifact? | Melone, M., et al. 2005. J Chem Neuroanat. 30: 45-54. PMID: 15923108
- Cloning, immunolocalization, and functional expression of a GABA transporter from the retina of the skate. | Birnbaum, AD., et al. 2005. Vis Neurosci. 22: 211-23. PMID: 15935113
- Developmental expression of GABA transporter-1 and 3 during formation of the GABAergic synapses in the mouse cerebellar cortex. | Takayama, C. and Inoue, Y. 2005. Brain Res Dev Brain Res. 158: 41-9. PMID: 16024093
- GAT-3 transporters regulate inhibition in the neocortex. | Kinney, GA. 2005. J Neurophysiol. 94: 4533-7. PMID: 16135550
- Alteration of the glutamate and GABA transporters in the hippocampus of the Niemann-Pick disease, type C mouse using proteomic analysis. | Byun, K., et al. 2006. Proteomics. 6: 1230-6. PMID: 16429462
- GAT1 and GAT3 expression are differently localized in the human epileptogenic hippocampus. | Lee, TS., et al. 2006. Acta Neuropathol. 111: 351-63. PMID: 16456667
- New highly potent GABA uptake inhibitors selective for GAT-1 and GAT-3 derived from (R)- and (S)-proline and homologous pyrrolidine-2-alkanoic acids. | Fülep, GH., et al. 2006. Eur J Med Chem. 41: 809-24. PMID: 16766089
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GABA T-3 Antibody (G-6) | sc-376001 | 200 µg/ml | $322.00 | |||
GABA T-3 Antibody (G-6) AC | sc-376001 AC | 500 µg/ml, 25% agarose | $424.00 | |||
GABA T-3 Antibody (G-6) HRP | sc-376001 HRP | 200 µg/ml | $322.00 | |||
GABA T-3 Antibody (G-6) FITC | sc-376001 FITC | 200 µg/ml | $336.00 | |||
GABA T-3 Antibody (G-6) PE | sc-376001 PE | 200 µg/ml | $349.00 | |||
GABA T-3 Antibody (G-6) Alexa Fluor® 488 | sc-376001 AF488 | 200 µg/ml | $364.00 | |||
GABA T-3 Antibody (G-6) Alexa Fluor® 546 | sc-376001 AF546 | 200 µg/ml | $364.00 | |||
GABA T-3 Antibody (G-6) Alexa Fluor® 594 | sc-376001 AF594 | 200 µg/ml | $364.00 | |||
GABA T-3 Antibody (G-6) Alexa Fluor® 647 | sc-376001 AF647 | 200 µg/ml | $364.00 | |||
GABA T-3 Antibody (G-6) Alexa Fluor® 680 | sc-376001 AF680 | 200 µg/ml | $364.00 | |||
GABA T-3 Antibody (G-6) Alexa Fluor® 790 | sc-376001 AF790 | 200 µg/ml | $364.00 | |||
GABA T-3 (G-6) Neutralizing Peptide | sc-376001 P | 100 µg/0.5 ml | $69.00 |