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FURA-PE3/AM (CAS 172890-84-5)

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Application:
FURA-PE3/AM is an acetoxymethyl derivative of FURA-PE3 with spectral properties
CAS Number:
172890-84-5
Purity:
>95%
Molecular Weight:
1258.10
Molecular Formula:
C55H63N5O29
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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FURA-PE3/AM with spectral properties is similar to the parent compound. Can be loaded into cells in a manner similar to FURA 2/AM. Hydrolysis by non-specific esterases traps the indicator in the cytosol. Compared to FURA-2, it is retained longer in the cell.


FURA-PE3/AM (CAS 172890-84-5) References

  1. Dexamethasone-mediated inhibition of calcium transients and ACTH release in a pituitary cell line (AtT-20).  |  Loechner, KJ., et al. 1999. Steroids. 64: 404-12. PMID: 10433177
  2. Halothane decreases calcium sensitivity of rat aortic smooth muscle.  |  Kakuyama, M., et al. 1999. Can J Anaesth. 46: 1164-71. PMID: 10608212
  3. Characteristics of collagen-induced Ca2+ mobilization in bovine platelets.  |  Shiraishi, M., et al. 2000. Cell Calcium. 27: 53-60. PMID: 10726211
  4. Determination of the physical environment within the Chlamydia trachomatis inclusion using ion-selective ratiometric probes.  |  Grieshaber, S., et al. 2002. Cell Microbiol. 4: 273-83. PMID: 12027956
  5. D-galactosamine induced hepatocyte apoptosis is inhibited in vivo and in cell culture by a calcium calmodulin antagonist, chlorpromazine, and a calcium channel blocker, verapamil.  |  Tsutsui, S., et al. 2003. Exp Anim. 52: 43-52. PMID: 12638236
  6. Depletion of intracellular Ca2+ store itself may be a major factor in thapsigargin-induced ER stress and apoptosis in PC12 cells.  |  Yoshida, I., et al. 2006. Neurochem Int. 48: 696-702. PMID: 16481070
  7. Long-lasting spontaneous calcium transients in the striatal cells.  |  Osanai, M., et al. 2006. Neurosci Lett. 402: 81-5. PMID: 16714081
  8. Intracellular calcium mobilization of the aganglionic intestine in the endothelin B receptor gene-deficient rat.  |  Nakatsuji, T., et al. 2007. J Pediatr Surg. 42: 1663-70. PMID: 17923193
  9. Mechanism of Rho-kinase-mediated Ca2+-independent contraction in aganglionic smooth muscle in a rat model of Hirschsprung's disease.  |  Akiyoshi, J., et al. 2009. Pediatr Surg Int. 25: 955-60. PMID: 19693518
  10. Cell Cycle-Dependent Localization of Voltage-Dependent Calcium Channels and the Mitotic Apparatus in a Neuroendocrine Cell Line(AtT-20).  |  Loechner, KJ., et al. 2009. Int J Cell Biol. 2009: 487959. PMID: 20130814
  11. Cholesterol enrichment of rabbit platelets enhances the Ca(2+) entry pathway induced by platelet-derived secondary feedback agonists.  |  Shiraishi, M., et al. 2013. Life Sci. 92: 838-44. PMID: 23499558
  12. Mibefradil, a T-type Ca2+ channel blocker also blocks Orai channels by action at the extracellular surface.  |  Li, P., et al. 2019. Br J Pharmacol. 176: 3845-3856. PMID: 31271653
  13. Protective effects of dapagliflozin against oxidative stress-induced cell injury in human proximal tubular cells.  |  Zaibi, N., et al. 2021. PLoS One. 16: e0247234. PMID: 33606763
  14. Mechanism of relaxant effect of clonidine in isolated bovine tracheal smooth muscle.  |  Arimitsu, M., et al. 1998. J Pharmacol Exp Ther. 286: 681-7. PMID: 9694921

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

FURA-PE3/AM, 50 µg

sc-203960
50 µg
$75.00

Is FURA-PE3/AM (CAS 172890-84-5) cell permeant?

Asked by: siri2
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Answered by: Tech Service 1
Date published: 2021-05-14
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Rated 5 out of 5 by from Various publications cite FURAVarious publications cite FURA-PE3/AM as a derivative with spectral properties similar to the parent compound. Can be loaded into cells in a manner similar to FURA 2/AM . Hydrolysis by non-specific esterases traps the indicator in the cytosol. Compared to FURA-2 , it is retained longer in the cell. -SCBT Publication Review
Date published: 2015-01-08
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FURA-PE3/AM is rated 5.0 out of 5 by 1.
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