Date published: 2025-10-18

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FSB (CAS 760988-03-2)

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Alternate Names:
(E,E)-1-Fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene
Application:
FSB is useful for staining plaques and neurofibrillary tangles
CAS Number:
760988-03-2
Purity:
≥95%
Molecular Weight:
420.39
Molecular Formula:
C24H17FO6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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FSB (Fluorosulfurylbenzoyl) is a chemical compound, particularly known for its mechanism of action that has made it a subject of interest in various research areas, especially in organic and analytical chemistry. The molecule consists of a benzoyl group attached to a fluorosulfuryl group, a unique combination that imparts distinctive reactive properties. This chemical structure allows FSB to act as a highly reactive electrophilic agent, capable of undergoing various complex chemical reactions. Researchers have found that its reactivity can be harnessed for the synthesis of diverse organic compounds, making it useful in the development of new synthetic methodologies. Moreover, its ability to introduce fluorine-containing groups into other molecules has made it particularly useful in the study of fluorination reactions, a critical area in organic chemistry given the importance of fluorinated compounds in numerous industrial applications. The specific interactions and transformations FSB undergoes have provided deep insights into reaction mechanisms and molecular interactions, advancing the understanding of chemical reactivity principles. Therefore, FSB′s role extends beyond its immediate chemical properties, serving as a cornerstone in exploratory research that helps unravel the complexities of chemical reactions and molecular structures.


FSB (CAS 760988-03-2) References

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  2. Bullous amyloidosis mimicking bullous pemphigoid: usefulness of electron microscopic examination.  |  Asahina, A., et al. 2010. Acta Derm Venereol. 90: 427-8. PMID: 20574619
  3. Congo red, an amyloid-inhibiting compound, alleviates various types of cellular dysfunction triggered by mutant protein kinase cγ that causes spinocerebellar ataxia type 14 (SCA14) by inhibiting oligomerization and aggregation.  |  Seki, T., et al. 2010. J Pharmacol Sci. 114: 206-16. PMID: 20938103
  4. Temporal changes of CD68 and α7 nicotinic acetylcholine receptor expression in microglia in Alzheimer's disease-like mouse models.  |  Matsumura, A., et al. 2015. J Alzheimers Dis. 44: 409-23. PMID: 25352454
  5. Propagation of pathological α-synuclein in marmoset brain.  |  Shimozawa, A., et al. 2017. Acta Neuropathol Commun. 5: 12. PMID: 28148299
  6. State-of-the-Art Fluorescence Fluctuation-Based Spectroscopic Techniques for the Study of Protein Aggregation.  |  Kitamura, A. and Kinjo, M. 2018. Int J Mol Sci. 19: PMID: 29570669
  7. Dynamic assessment of tau immunotherapies in the brains of live animals by two-photon imaging.  |  Wu, Q., et al. 2018. EBioMedicine. 35: 270-278. PMID: 30146345
  8. Orientation of a Diagnostic Ligand Bound to Macroscopically Aligned Amyloid-β Fibrils Determined by Solid-State NMR.  |  Townsend, D., et al. 2018. J Phys Chem Lett. 9: 6611-6615. PMID: 30354142
  9. Neuroinflammation in mouse models of Alzheimer's disease.  |  Saito, T. and Saido, TC. 2018. Clin Exp Neuroimmunol. 9: 211-218. PMID: 30546389
  10. CD14 and Toll-Like Receptor 4 Promote Fibrillar Aβ42 Uptake by Microglia Through A Clathrin-Mediated Pathway.  |  Fujikura, M., et al. 2019. J Alzheimers Dis. 68: 323-337. PMID: 30775984
  11. In vivo detection of tau fibrils and amyloid β aggregates with luminescent conjugated oligothiophenes and multiphoton microscopy.  |  Calvo-Rodriguez, M., et al. 2019. Acta Neuropathol Commun. 7: 171. PMID: 31703739
  12. Amyloid fibril formation is suppressed in microgravity.  |  Matsushita, H., et al. 2021. Biochem Biophys Rep. 25: 100875. PMID: 33364446
  13. Accumulation of cellular prion protein within β-amyloid oligomer plaques in aged human brains.  |  Takahashi, RH., et al. 2021. Brain Pathol. 31: e12941. PMID: 33624334
  14. Endothelial expression of human amyloid precursor protein leads to amyloid β in the blood and induces cerebral amyloid angiopathy in knock-in mice.  |  Tachida, Y., et al. 2022. J Biol Chem. 298: 101880. PMID: 35367207
  15. Phenol-Soluble Modulins From Staphylococcus aureus Biofilms Form Complexes With DNA to Drive Autoimmunity.  |  Grando, K., et al. 2022. Front Cell Infect Microbiol. 12: 884065. PMID: 35646719

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

FSB, 5 mg

sc-359845
5 mg
$471.00