Date published: 2025-12-5

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Fmoc-N-Me-Leu-OH (CAS 103478-62-2)

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Alternate Names:
Fmoc-N-methyl-L-leucine
CAS Number:
103478-62-2
Molecular Weight:
367.44
Molecular Formula:
C22H25NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Fmoc-N-Me-Leu-OH (Fmoc-NMeLeu) emerges as a highly versatile and widely employed amino acid derivative. Fmoc-N-Me-Leu-OH serves as a protected form of the essential amino acid leucine. It has played a vital role in investigations involving protein structure, enzyme activity, and gene expression. Moreover, Fmoc-N-Me-Leu-OH has been integral to studies exploring cell signaling and serving as a substrate for protein conjugation. Additionally, its utility extends to peptide synthesis, solid-phase synthesis, and bioconjugation. The precise mechanism of action for Fmoc-N-Me-Leu-OH remains partially understood. However, it is believed that the Fmoc protecting group effectively shields the amino acid.


Fmoc-N-Me-Leu-OH (CAS 103478-62-2) References

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  2. Design, synthesis and biological evaluation of phosphopeptides as Polo-like kinase 1 Polo-box domain inhibitors.  |  Lin, TY., et al. 2018. Bioorg Med Chem. 26: 3429-3437. PMID: 29807699
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  6. Synthesis of Marine Cyclopeptide Galaxamide Analogues as Potential Anticancer Agents.  |  Li, D., et al. 2022. Mar Drugs. 20: PMID: 35323457
  7. Solid‐Phase Total Synthesis of the Proposed Structure of Coibamide A and Its Derivative: Highly Methylated Cyclic Depsipeptides  |  Sable, G. A., Park, J., Kim, H., Lim, S. J., Jang, S., & Lim, D. 2015. European Journal of Organic Chemistry. 2015(32): 7043-7052.
  8. Solid‐phase Total Synthesis of Amide Analogues of Coibamide A: Azacoibamide A and O‐Desmethyl Azacoibamide A  |  Sable, G. A., Park, J., Lim, S. J., & Lim, D. 2016. Bulletin of the Korean Chemical Society. 37(3): 330-334.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Fmoc-N-Me-Leu-OH, 1 g

sc-460738
1 g
$40.00

Fmoc-N-Me-Leu-OH, 5 g

sc-460738A
5 g
$160.00