Date published: 2025-12-5

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Fmoc-Lys-OH hydrochloride (CAS 139262-23-0)

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Alternate Names:
Nα-Fmoc-L-lysine hydrochloride
CAS Number:
139262-23-0
Molecular Weight:
404.89
Molecular Formula:
C21H24N2O4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Fmoc-Lys-OH hydrochloride is a highly versatile and widely employed reagent in the realm of organic synthesis. This compound is derived from the amino acid L-lysine, wherein a fluorenylmethyloxycarbonyl (Fmoc) group is attached to the amino group. Within the domain of scientific research, Fmoc-Lys-OH hydrochloride finds extensive utilization, particularly in peptide and protein synthesis. Its incorporation enables the modification of peptide and protein properties, facilitating the synthesis of intricate molecules. Furthermore, Fmoc-Lys-OH hydrochloride plays a pivotal role in the synthesis of diverse compounds such as small molecules, polymers, and metal complexes. As an amino acid derivative, Fmoc-Lys-OH hydrochloride operates based on its capacity to react with other molecules. It engages in the formation of peptide bonds when reacting with other molecules and can also participate in reactions with functional groups, such as carboxyl groups, leading to the creation of esters.


Fmoc-Lys-OH hydrochloride (CAS 139262-23-0) References

  1. N-methyl-phenacyloxycarbamidomethyl (Pocam) group: a novel thiol protecting group for solid-phase peptide synthesis and peptide condensation reactions.  |  Katayama, H., et al. 2011. Org Biomol Chem. 9: 4653-61. PMID: 21537511
  2. Site-specific labeling of synthetic peptide using the chemoselective reaction between N-methoxyamino acid and isothiocyanate.  |  Hara, T., et al. 2015. J Pept Sci. 21: 765-9. PMID: 26358741
  3. Site-Specific Installation of Succinyl Lysine Analog into Histones Reveals the Effect of H2BK34 Succinylation on Nucleosome Dynamics.  |  Jing, Y., et al. 2018. Cell Chem Biol. 25: 166-174.e7. PMID: 29249693
  4. New Targeted Gold Nanorods for the Treatment of Glioblastoma by Photodynamic Therapy.  |  Youssef, Z., et al. 2019. J Clin Med. 8: PMID: 31847227
  5. DNA-Protein Cross-Links Formed by Reacting Lysine with Apurinic/Apyrimidinic Sites in DNA and Human Cells: Quantitative Analysis by Liquid Chromatography-Tandem Mass Spectrometry Coupled with Stable Isotope Dilution.  |  Chan, W. and Jin, L. 2022. Anal Chem. 94: 803-810. PMID: 34971314
  6. Design of a Targeting and Oxygen-Independent Platform to Improve Photodynamic Therapy: A Proof of Concept.  |  Larue, L., et al. 2021. ACS Appl Bio Mater. 4: 1330-1339. PMID: 35014484

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Fmoc-Lys-OH hydrochloride, 5 g

sc-228191
5 g
$138.00