Date published: 2025-9-26

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Fluasterone (CAS 112859-71-9)

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Application:
Fluasterone is a synthetic derivative of Dehydroepiandrosterone
CAS Number:
112859-71-9
Molecular Weight:
290.42
Molecular Formula:
C19H27FO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Fluasterone interacts with cellular components by binding to and activating the androgen receptor, leading to the regulation of gene expression. It inhibits the enzyme 17β-hydroxysteroid dehydrogenase, which is involved in the conversion of estrone to estradiol. This dual mechanism of action influences cellular processes such as cell growth, differentiation, and apoptosis. Fluasterone modulates the production of cytokines and growth factors, impacting immune responses and inflammation. It affects lipid metabolism and insulin sensitivity, contributing to its potential role in metabolic disorders. Fluasterone influences neurotransmitter systems in the brain, potentially affecting mood and behavior. Fluasterone′s interactions with cellular components have broad implications for various physiological processes, making it a compound of interest for further study.


Fluasterone (CAS 112859-71-9) References

  1. Inhibition of adjuvant-induced arthritis by 16 alpha-fluoro-5-androsten-17-one.  |  Schwartz, AG. and Pashko, LL. 2002. Mil Med. 167: 60-3. PMID: 11873519
  2. Inhibition of carcinogen-activating enzymes by 16alpha-fluoro-5-androsten-17-one.  |  Ciolino, HP., et al. 2002. Cancer Res. 62: 3685-90. PMID: 12097275
  3. A synthetic androstene derivative and a natural androstene metabolite inhibit relapsing-remitting EAE.  |  Offner, H., et al. 2002. J Neuroimmunol. 130: 128-39. PMID: 12225895
  4. Solubilization of Fluasterone in cosolvent/cyclodextrin combinations.  |  He, Y., et al. 2003. Int J Pharm. 264: 25-34. PMID: 12972333
  5. Neuroimmunoprotective effects of estrogen and derivatives in experimental autoimmune encephalomyelitis: therapeutic implications for multiple sclerosis.  |  Offner, H. 2004. J Neurosci Res. 78: 603-24. PMID: 15515048
  6. Molecular specificity of 5-androstenediol as a systemic radioprotectant in mice.  |  Whitnall, MH., et al. 2005. Immunopharmacol Immunotoxicol. 27: 15-32. PMID: 15803857
  7. Complete 1H and 13C assignments of fluorinated analogs of dehydroepiandrosterone.  |  Burgess, JP., et al. 2006. Magn Reson Chem. 44: 1051-3. PMID: 16835888
  8. Chemoprevention of rat prostate carcinogenesis by dietary 16alpha-fluoro-5-androsten-17-one (fluasterone), a minimally androgenic analog of dehydroepiandrosterone.  |  McCormick, DL., et al. 2007. Carcinogenesis. 28: 398-403. PMID: 16952912
  9. Evaluation of cancer chemopreventive agents using clones derived from a human prostate cancer cell line.  |  Ware, JH., et al. 2006. Anticancer Res. 26: 4177-83. PMID: 17201130
  10. Chemopreventive drug development: perspectives and progress.  |  Kelloff, GJ., et al. 1994. Cancer Epidemiol Biomarkers Prev. 3: 85-98. PMID: 8118391

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Fluasterone, 10 mg

sc-211514
10 mg
$372.00

Fluasterone, 100 mg

sc-211514A
100 mg
$2825.00

Fluasterone, 1 g

sc-211514B
1 g
$13265.00

Fluasterone, 5 g

sc-211514C
5 g
$40295.00