fetuin-B Antibody (LL9): sc-73978

Fetuin-B Antibody (LL9) is a mouse monoclonal IgG1 antibody that detects fetuin-B of human origin by western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Anti-fetuin-B antibody (LL9) is available as the non-conjugated format. Fetuin-B is a secreted protein primarily expressed in the liver and testis, playing a crucial role in various physiological processes. One of its significant functions involves calcium homeostasis; fetuin-B preferentially binds to calcium ions in the bloodstream, which is essential for maintaining mineral balance and preventing pathological calcification. This regulation is particularly important in conditions such as osteoporosis and cardiovascular diseases, where calcium dysregulation can lead to severe complications. Additionally, fetuin-B has been implicated in the modulation of immune response, acting as an acute phase anti-inflammatory mediator that helps regulate innate immune response following tissue injury. During inflammatory states, circulating fetuin-B levels decrease significantly as fetuin-B associates with macrophage membranes, enhancing the uptake of cationic small molecules and facilitating macrophage deactivation. The biologically active form of fetuin-B is derived from a precursor protein that undergoes cleavage at the amino terminus, resulting in two chains linked by a single disulfide bond. This intricate structure and function underscore fetuin-B′s importance in both mineral metabolism and immune regulation, making fetuin-B monoclonal antibody (LL9) a valuable tool for researchers studying these critical biological processes.

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fetuin-B Antibody (LL9) References:

1. Fetuin-B, a second member of the fetuin family in mammals.  |  Olivier, E., et al. 2000. Biochem J. 350 Pt 2: 589-97. PMID: 10947975
2. Human alpha 2-HS-glycoprotein: the A and B chains with a connecting sequence are encoded by a single mRNA transcript.  |  Lee, CC., et al. 1987. Proc Natl Acad Sci U S A. 84: 4403-7. PMID: 3474608
3. The serum protein alpha2-HS glycoprotein/fetuin inhibits apatite formation in vitro and in mineralizing calvaria cells. A possible role in mineralization and calcium homeostasis.  |  Schinke, T., et al. 1996. J Biol Chem. 271: 20789-96. PMID: 8702833
4. Serum concentration of human alpha 2 HS glycoprotein during the inflammatory process: evidence that alpha 2 HS glycoprotein is a negative acute-phase reactant.  |  Lebreton, JP., et al. 1979. J Clin Invest. 64: 1118-29. PMID: 90057
5. Structure of the gene encoding human alpha 2-HS glycoprotein (AHSG).  |  Osawa, M., et al. 1997. Gene. 196: 121-5. PMID: 9322749
6. Modification of macrophage response to lipopolysaccharide by fetuin.  |  Dziegielewska, KM., et al. 1998. Immunol Lett. 60: 31-5. PMID: 9541460
7. Structural and functional analysis of the 5'-transcription control region for the human alpha2-HS glycoprotein gene.  |  Banine, F., et al. 1998. Biochim Biophys Acta. 1398: 1-8. PMID: 9602019
8. Fetuin (alpha2-HS-glycoprotein) opsonizes cationic macrophagedeactivating molecules.  |  Wang, H., et al. 1998. Proc Natl Acad Sci U S A. 95: 14429-34. PMID: 9826717

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-fetuin-B Antibody (LL9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-fetuin-B Antibody (LL9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

fetuin-B Antibody (LL9) Specifications

Alternate Product Name: fetuin-B

Product Clone Name: LL9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: fetuin-B

Epitope Species: human

Product Reactivity/Detection: fetuin-B

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and protein stabilizer

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for fetuin-B Antibody (LL9): N/A