FeLV gp85/gp70 Antibody (C11D8): sc-65621

FeLV gp85/gp70 Antibody (C11D8) is a mouse monoclonal IgG antibody that detects the Env gp85 and Env gp70 proteins of feline leukemia virus (FeLV) origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). FeLV gp85/gp70 (C11D8) antibody is available in a non-conjugated form, providing researchers with a versatile tool for studying this important retrovirus. The feline leukemia virus, primarily transmitted through saliva or nasal secretions, can also spread via urine, feces, or milk, leading to infection of epithelial cells, tonsillar B lymphocytes, and macrophages. Once in the bloodstream, FeLV can cause viremia and, if FeLV infiltrates the bone marrow, FeLV can persist for the cat′s lifetime, resulting in significant immunosuppression and a mortality rate of approximately 30% among infected individuals. Among the various envelope proteins associated with FeLV, glycoproteins gp27, gp70, and gp85 are critical for diagnosis and understanding the virus′s pathogenesis. Notably, the development of a high concentration of cytotoxic antibodies against FeLV gp70 has been linked to tumor regression and the potential clearance of FeLV infection, highlighting the importance of these proteins in both disease progression and therapeutic responses.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

FeLV gp85/gp70 Antibody (C11D8) References:

1. Infections of feline leukemia virus and feline immunodeficiency virus.  |  Miyazawa, T. 2002. Front Biosci. 7: d504-18. PMID: 11815291
2. Host range and receptor binding properties of vectors bearing feline leukemia virus subgroup B envelopes can be modulated by envelope sequences outside of the receptor binding domain.  |  Faix, PH., et al. 2002. J Virol. 76: 12369-75. PMID: 12414980
3. Feline leukemia virus threatens endangered panthers.  |  Nolen, RS. 2004. J Am Vet Med Assoc. 224: 1721-2. PMID: 15198250
4. Prevalence of canine distemper virus, feline immunodeficiency virus and feline leukemia virus in captive African lions (Panthera leo) in Japan.  |  Endo, Y., et al. 2004. J Vet Med Sci. 66: 1587-9. PMID: 15644613
5. Re-examination of feline leukemia virus: host relationships using real-time PCR.  |  Torres, AN., et al. 2005. Virology. 332: 272-83. PMID: 15661159
6. Shedding of feline leukemia virus RNA in saliva is a consistent feature in viremic cats.  |  Gomes-Keller, MA., et al. 2006. Vet Microbiol. 112: 11-21. PMID: 16303261
7. Rapid detection of feline leukemia virus provirus integration into feline genomic DNA.  |  Cattori, V., et al. 2006. Mol Cell Probes. 20: 172-81. PMID: 16488115
8. Clearance of feline leukemia virus from persistently infected pet cats treated by extracorporeal immunoadsorption is correlated with an enhanced antibody response to FeLV gp 70.  |  Snyder, HW., et al. 1984. J Immunol. 132: 1538-43. PMID: 6319496
9. Appearance of cytotoxic antibody to viral gp70 on feline lymphoma cells (FL-74) in cats during ex vivo immunoadsorption therapy: quantitation, characterization, and association with remission of disease and disappearance of viremia.  |  Liu, WT., et al. 1984. Proc Natl Acad Sci U S A. 81: 3516-20. PMID: 6328520

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FeLV gp85/gp70 Antibody (C11D8) has 1 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FeLV gp85/gp70 Antibody (C11D8) Specifications

Alternate Product Name: FeLV gp85/gp70

Product Clone Name: C11D8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 214-218

Epitope Target: FeLV gp85/gp70

Epitope Species: FeLV

Product Reactivity/Detection: Env gp85 and Env gp70

Species Reactivity/Detection: FeLV

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for FeLV gp85/gp70 Antibody (C11D8): N/A