FAT4 Antibody (1654CT645.1.70): sc-517330

FAT4 Antibody (1654CT645.1.70) is a mouse monoclonal IgG1 kappa light chain antibody that detects FAT4 protein of human origin by western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Anti-FAT4 antibody (1654CT645.1.70) is available as a non-conjugated monoclonal isotype antibody. FAT4 protein, also known as FAT tumor suppressor homolog 4, plays a crucial role in regulating planar cell polarity, which is essential for proper tissue organization and development. This 4,981 amino acid single-pass type I membrane protein is predominantly localized to primary cilia of kidney cells, where FAT4 contributes to maintaining cellular architecture and signaling pathways. FAT4 protein is characterized by an extensive structure, containing thirty-four cadherin domains, six EGF-like domains, and two laminin G-like domains, which facilitate interactions with other proteins and influence adhesive properties. FAT4′s ability to interact with cytoplasmic proteins, such as β-catenin, underscores FAT4′s importance in mediating cell-cell adhesion and maintaining tissue integrity. Given widespread expression and functional significance, FAT4 protein is a key player in developmental processes and may have implications in various diseases, including cancer, where disruptions in cell polarity and adhesion are often observed.

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FAT4 Antibody (1654CT645.1.70) References:

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