FAST-1/2 Antibody (H-7): sc-376888
- FAST-1/2 Antibody (H-7) is a mouse monoclonal IgM κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-29 at the N-terminus of FAST-2 of mouse origin
- recommended for detection of FAST-1 and FAST-2 of mouse and rat origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for FAST-1/2 Antibody (H-7). This work is in progress.
FAST-1/2 Antibody (H-7) is a mouse monoclonal IgM antibody that detects FAST-1/2 in mouse and rat species through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). FAST-1/2 is a crucial transcription factor that plays a significant role in embryonic development and cellular differentiation by forming a complex with the receptor-regulated Smad protein, Smad2, and binding to activin response elements on DNA. The protein′s structure includes a conserved N-terminal forkhead domain, which is essential for DNA-binding capability and transcriptional regulation, as well as a distinct C-terminal Smad interaction domain that facilitates association with various Smad proteins, including Smad2, Smad3, and Smad4. This structural organization is vital for mediating TGFβ-induced signal transduction, as FAST-1 and FAST-2 expression is predominantly observed during early developmental stages, with diminished levels in adult tissues. FAST-1/2′s ability to regulate gene expression in response to TGFβ and activin highlights its importance in developmental biology and tumorigenesis, making anti-FAST-1/2 antibody (H-7) an essential tool for researchers studying these critical processes.
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FAST-1/2 Antibody (H-7) References:
- Regulation of the Lim-1 gene is mediated through conserved FAST-1/FoxH1 sites in the first intron. | Watanabe, M., et al. 2002. Dev Dyn. 225: 448-56. PMID: 12454922
- Repeat treatment of acute hereditary angioedema attacks with open-label icatibant in the FAST-1 trial. | Malbrán, A., et al. 2014. Clin Exp Immunol. 177: 544-53. PMID: 24749847
- FAST-1 antisense RNA epigenetically alters FXN expression. | Mikaeili, H., et al. 2018. Sci Rep. 8: 17217. PMID: 30464193
- Ultra-compact ultra-fast 1-bit comparator based on a two-dimensional nonlinear photonic crystal structure. | Seraj, Z., et al. 2020. Appl Opt. 59: 811-816. PMID: 32225213
- Excited Precursor Reactivity, Fast 1,2-H Shifts, and Diffusion-Controlled Methanol Insertion in 1,2-Diphenylalkylidenes. | Motschiedler, K., et al. 1999. J Org Chem. 64: 5139-5147. PMID: 34237870
- Artifact suppression in readout-segmented consistent K-t space EPSI (RS-COKE) for fast 1 H spectroscopic imaging at 7 T. | Seginer, A., et al. 2022. Magn Reson Med. 88: 2339-2357. PMID: 35975965
- Microwave Synthesis of Visible-Light-Activated g-C3N4/TiO2 Photocatalysts. | Matias, ML., et al. 2023. Nanomaterials (Basel). 13: PMID: 36985984
- Human dynein-dynactin is a fast processive motor in living cells. | Verma, V., et al. 2023. bioRxiv.. PMID: 38076961
- MISSTEC-S: A fast 1H pulse calibration from spectra simultaneously produced by a spin echo and a stimulated echo. | Sanchez, M., et al. 2024. J Magn Reson. 364: 107712. PMID: 38879927
- Smad4 and FAST-1 in the assembly of activin-responsive factor. | Chen, X., et al. 1997. Nature. 389: 85-9. PMID: 9288972
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FAST-1/2 Antibody (H-7) | sc-376888 | 200 µg/ml | $322.00 | |||
FAST-1/2 (H-7) Neutralizing Peptide | sc-376888 P | 100 µg/0.5 ml | $69.00 | |||
FAST-1/2 Antibody (H-7) X | sc-376888 X | 200 µg/0.1 ml | $322.00 |