FAM107B Antibody (D-4): sc-515361

FAM107B Antibody (D-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects FAM107B protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-FAM107B antibody (D-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. FAM107B protein, consisting of 131 amino acids, plays a crucial role in cellular processes, particularly in regulating cell proliferation and apoptosis, which are vital for maintaining normal tissue homeostasis and preventing tumorigenesis. Dysregulation of FAM107B has been implicated in various cancers, highlighting FAM107B′s importance as a potential biomarker and therapeutic target. FAM107B is located on human chromosome 10, a region that harbors several critical genes, including tumor suppressor gene PTEN, which is associated with Cowden syndrome when mutated. Additionally, chromosome 10 is linked to other significant genetic disorders, emphasizing the relevance of studying FAM107B in the context of cancer and genetic diseases.

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FAM107B Antibody (D-4) References:

1. Complete absence of Cockayne syndrome group B gene product gives rise to UV-sensitive syndrome but not Cockayne syndrome.  |  Horibata, K., et al. 2004. Proc Natl Acad Sci U S A. 101: 15410-5. PMID: 15486090
2. Cowden syndrome-affected patients with PTEN promoter mutations demonstrate abnormal protein translation.  |  Teresi, RE., et al. 2007. Am J Hum Genet. 81: 756-67. PMID: 17847000
3. First report of ovarian dysgerminoma in Cowden syndrome with germline PTEN mutation and PTEN-related 10q loss of tumor heterozygosity.  |  Cho, MY., et al. 2008. Am J Surg Pathol. 32: 1258-64. PMID: 18594467
4. PTEN hamartoma tumor syndromes.  |  Blumenthal, GM. and Dennis, PA. 2008. Eur J Hum Genet. 16: 1289-300. PMID: 18781191
5. PTEN: a new guardian of the genome.  |  Yin, Y. and Shen, WH. 2008. Oncogene. 27: 5443-53. PMID: 18794879
6. Kabuki syndrome and trisomy 10p.  |  Utine, GE., et al. 2008. Genet Couns. 19: 291-300. PMID: 18990985
7. Apparent late-onset Cockayne syndrome and interstitial deletion of the long arm of chromosome 10 (del(10)(q11.23q21.2)).  |  Fryns, JP., et al. 1991. Am J Med Genet. 40: 343-4. PMID: 1951442
8. Chromosomal location of two human genes encoding tetrahydrobiopterin-metabolizing enzymes: 6-pyruvoyl-tetrahydropterin synthase maps to 11q22.3-q23.3, and pterin-4 alpha-carbinolamine dehydratase maps to 10q22.  |  Thöny, B., et al. 1994. Genomics. 19: 365-8. PMID: 8188266

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FAM107B Antibody (D-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-FAM107B Antibody (D-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FAM107B Antibody (D-4) Specifications

Alternate Product Name: FAM107B

Product Clone Name: D-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 113-131

Epitope Target: FAM107B

Epitope Species: human

Product Reactivity/Detection: FAM107B

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for FAM107B Antibody (D-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin