Factor XII light chain Antibody (1.B.694): sc-71093

Factor XII Antibody (1.B.694) is a mouse monoclonal IgG1 antibody that detects Factor XII in human samples through enzyme-linked immunosorbent assay (ELISA). Factor XII, also known as Hageman factor, plays a crucial role in the hemostatic process by initiating the coagulation cascade, which is vital for forming stable fibrin clots and ensuring proper wound healing. Factor XII is primarily located in the plasma, where Factor XII circulates in an inactive form until activated by contact with negatively charged surfaces, such as those found on damaged tissues. The activation of Factor XII is essential for the subsequent activation of Factor XI and prekallikrein, leading to a series of reactions that culminate in fibrin clot formation. Understanding the location and activation mechanism of Factor XII is important, as deficiencies or dysregulations in Factor XII can lead to thromboembolic disorders, highlighting Factor XII′s significance in maintaining vascular integrity and preventing excessive bleeding. Factor XII (1.B.694) antibody is an invaluable tool for researchers studying coagulation pathways and related disorders, providing insights into the complex interactions that govern hemostasis.

The preferred Factor XII antibody is Factor XII Antibody (C-8): sc-376770.