Molecular structure of FAAH Inhibitor II, CAS Number: 546141-08-6
FAAH Inhibitor II (CAS 546141-08-6)
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Alternate Names:
URB-597
Application:
FAAH Inhibitor II is a cell permeable carbamate and potent inhibitor of fatty acid amide hydrolase (FAHH)
CAS Number:
546141-08-6
Purity:
≥98%
Molecular Weight:
338.4
Molecular Formula:
C20H22N2O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
FAAH Inhibitor II is a cell-permeable carbamate compound that acts as a potent, selective, and irreversible inhibitor of FAAH (fatty acid amide hydrolase IC50 = 4.6 nM in brain membranes). Shown to block anandamide breakdown in rat cortical neurons (IC50 = 500 pM) and modulate anxiety in rats (ID50 = 0.15 mg/Kg). Does not affect the activities of several serine hydrolases (IC50 > 30 muM), including AChE (acetylcholinesterase), BCh (butyrylcholinesterase) and MGL (monoglyceride lipase). FAAH Inhibitor II does not interfere with the binding of anandamide to cannabinoid receptors CB1 and CB2 (IC50 > 100 muM), as well as several ion-channels and neurotransmitter transporters.
FAAH Inhibitor II (CAS 546141-08-6) References
- The FAAH inhibitor URB-597 interferes with cisplatin- and nicotine-induced vomiting in the Suncus murinus (house musk shrew). | Parker, LA., et al. 2009. Physiol Behav. 97: 121-4. PMID: 19239915
- FAAH inhibitor, URB-597, promotes extinction and CB(1) antagonist, SR141716, inhibits extinction of conditioned aversion produced by naloxone-precipitated morphine withdrawal, but not extinction of conditioned preference produced by morphine in rats. | Manwell, LA., et al. 2009. Pharmacol Biochem Behav. 94: 154-62. PMID: 19698735
- Evidence for involvement of TRPA1 in the detection of vibrations by hair bundle mechanoreceptors in sea anemones. | Mahoney, JL., et al. 2011. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 197: 729-42. PMID: 21394510
- The fatty acid amide hydrolase inhibitor URB 597: interactions with anandamide in rhesus monkeys. | Stewart, JL. and McMahon, LR. 2011. Br J Pharmacol. 164: 655-66. PMID: 21449917
- Disruptive effects of the prototypical cannabinoid Δ⁹-tetrahydrocannabinol and the fatty acid amide inhibitor URB-597 on go/no-go auditory discrimination performance and olfactory reversal learning in rats. | Sokolic, L., et al. 2011. Behav Pharmacol. 22: 191-202. PMID: 21512341
- The effect of anandamide on uterine nitric oxide synthase activity depends on the presence of the blastocyst. | Sordelli, MS., et al. 2011. PLoS One. 6: e18368. PMID: 21559512
- Endogenous opioid and cannabinoid mechanisms are involved in the analgesic effects of celecoxib in the central nervous system. | Rezende, RM., et al. 2012. Pharmacology. 89: 127-36. PMID: 22415159
- Quantitative LC-MS/MS analysis of arachidonoyl amino acids in mouse brain with treatment of FAAH inhibitor. | Han, B., et al. 2013. Anal Biochem. 432: 74-81. PMID: 23044255
- Effects of cannabinoids and endocannabinoid hydrolysis inhibition on pentylenetetrazole-induced seizure and electroencephalographic activity in rats. | Vilela, LR., et al. 2013. Epilepsy Res. 104: 195-202. PMID: 23352737
- Endocannabinoid System and TRPV1 Receptors in the Dorsal Hippocampus of the Rats Modulate Anxiety-like Behaviors. | Hakimizadeh, E., et al. 2012. Iran J Basic Med Sci. 15: 795-802. PMID: 23493622
- A role for oleoylethanolamide in chronic lymphocytic leukemia. | Masoodi, M., et al. 2014. Leukemia. 28: 1381-7. PMID: 24413323
- Study the Effect of Endocannabinoid System on Rat Behavior in Elevated Plus-Maze. | Komaki, A., et al. 2015. Basic Clin Neurosci. 6: 147-53. PMID: 26904171
- Modulation of central endocannabinoid system results in gastric mucosal protection in the rat. | Tóth, VE., et al. 2018. Brain Res Bull. 139: 224-234. PMID: 29438780
- Effects of Fatty Acid Amide Hydrolase Inhibitors Acute Administration on the Positive and Cognitive Symptoms of Schizophrenia in Mice. | Kruk-Slomka, M., et al. 2019. Mol Neurobiol. 56: 7251-7266. PMID: 31004320
Inhibitor of:
Enzyme, and FAAH.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FAAH Inhibitor II, 5 mg | sc-202605 | 5 mg | $67.00 |