F-Amidine (CAS 877617-45-3)
Alternate Names:
N-[(1S)-1-(Aminocarbonyl)-4-[(2-fluoro-1-iminoethyl)amino]butyl]benzamide
CAS Number:
877617-45-3
Molecular Weight:
294.32
Molecular Formula:
C14H19FN4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Safety Information
SDS & Certificate of Analysis
F-Amidine is an inhibitor of Peptidyl arginine deiminase 4 (PAD4) activity with an IC50 value of 21.6 μM in an in vitro activity assay. It irreversibly inactivates (kinact/KI = 3,000 M-1min-1) PAD4 by covalently modifying an active site cysteine that is important for its catalytic activity. Dysregulated PAD4 activity has been implicated in cancer and rheumatoid arthritis. F-amidine also inhibits PAD1 and PAD3 with IC50 values of 29.5 and 350 μM, respectively. F-amidine is cytotoxic to HL-60, MCF7 and HT-29 cancer cell lines (IC50s = 0.5, 0.5 and 1 μM, respectively).
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
F-Amidine, 1 mg | sc-496343A | 1 mg | $250.00 | |||
F-Amidine, 2.5 mg | sc-496343 | 2.5 mg | $430.00 | |||
F-Amidine, 5 mg | sc-496343B | 5 mg | $740.00 | |||
F-Amidine, 10 mg | sc-496343C | 10 mg | $1393.00 | |||
F-Amidine, 20 mg | sc-496343D | 20 mg | $2540.00 |