EXOSC7 Antibody (A-1): sc-393686
- EXOSC7 Antibody (A-1) is a mouse monoclonal IgG1 κ EXOSC7 antibody provided at 200 µg/ml
- raised against amino acids 133-291 mapping at the C-terminus of EXOSC7 of human origin
- EXOSC7 Antibody (A-1) is recommended for detection of EXOSC7 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-EXOSC7 Antibody (A-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for EXOSC7 Antibody (A-1) for WB applications. These reagents are now offered in bundles with EXOSC7 Antibody (A-1) (see ordering information below).
EXOSC7 Antibody (A-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects EXOSC7 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-EXOSC7 antibody (A-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. EXOSC7, also known as exosome component 7, plays a crucial role in RNA metabolism as a component of the exosome complex, which is essential for the degradation of unstable mRNAs, particularly those containing AU-rich elements in their untranslated regions. This degradation process is vital for maintaining cellular homeostasis and regulating gene expression, as it prevents the accumulation of potentially harmful mRNAs. Additionally, EXOSC7 is localized in the nucleolus and is one of the six RNase-PH domain subunits that form a PNPase-like ring structure within the exosome, which is necessary for the processing of 7S pre-RNA. EXOSC7′s ability to interact with other proteins in the exosome complex underscores its importance in RNA processing and stability, making anti-EXOSC7 antibody (A-1) an invaluable tool for researchers studying RNA metabolism and related cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
EXOSC7 Antibody (A-1) References:
- AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. | Chen, CY., et al. 2001. Cell. 107: 451-64. PMID: 11719186
- Protein-protein interactions of hCsl4p with other human exosome subunits. | Raijmakers, R., et al. 2002. J Mol Biol. 315: 809-18. PMID: 11812149
- Autoantibodies directed to novel components of the PM/Scl complex, the human exosome. | Brouwer, R., et al. 2002. Arthritis Res. 4: 134-8. PMID: 11879549
- Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. | Raijmakers, R., et al. 2002. J Mol Biol. 323: 653-63. PMID: 12419256
- Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome. | Anderson, JR., et al. 2006. RNA. 12: 1810-6. PMID: 16912217
- Characterization of native and reconstituted exosome complexes from the hyperthermophilic archaeon Sulfolobus solfataricus. | Walter, P., et al. 2006. Mol Microbiol. 62: 1076-89. PMID: 17078816
- Gene expression profiles in squamous cell cervical carcinoma using array-based comparative genomic hybridization analysis. | Choi, YW., et al. 2007. Int J Gynecol Cancer. 17: 687-96. PMID: 17504382
- Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. | Nagase, T., et al. 1995. DNA Res. 2: 37-43. PMID: 7788527
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
EXOSC7 Antibody (A-1) | sc-393686 | 200 µg/ml | $316.00 | |||
EXOSC7 Antibody (A-1): m-IgG Fc BP-HRP Bundle | sc-527706 | 200 µg Ab; 10 µg BP | $354.00 | |||
EXOSC7 Antibody (A-1): m-IgG1 BP-HRP Bundle | sc-533079 | 200 µg Ab; 20 µg BP | $354.00 | |||
EXOSC7 Antibody (A-1) AC | sc-393686 AC | 500 µg/ml, 25% agarose | $416.00 | |||
EXOSC7 Antibody (A-1) HRP | sc-393686 HRP | 200 µg/ml | $316.00 | |||
EXOSC7 Antibody (A-1) FITC | sc-393686 FITC | 200 µg/ml | $330.00 | |||
EXOSC7 Antibody (A-1) PE | sc-393686 PE | 200 µg/ml | $343.00 | |||
EXOSC7 Antibody (A-1) Alexa Fluor® 488 | sc-393686 AF488 | 200 µg/ml | $357.00 | |||
EXOSC7 Antibody (A-1) Alexa Fluor® 546 | sc-393686 AF546 | 200 µg/ml | $357.00 | |||
EXOSC7 Antibody (A-1) Alexa Fluor® 594 | sc-393686 AF594 | 200 µg/ml | $357.00 | |||
EXOSC7 Antibody (A-1) Alexa Fluor® 647 | sc-393686 AF647 | 200 µg/ml | $357.00 | |||
EXOSC7 Antibody (A-1) Alexa Fluor® 680 | sc-393686 AF680 | 200 µg/ml | $357.00 | |||
EXOSC7 Antibody (A-1) Alexa Fluor® 790 | sc-393686 AF790 | 200 µg/ml | $357.00 |