Molecular structure of Ethyl β-carboline-3-carboxylate (β-CCE), CAS Number: 74214-62-3
Ethyl β-carboline-3-carboxylate (β-CCE) (CAS 74214-62-3)
Application:
Ethyl β-carboline-3-carboxylate (β-CCE) is an inverse agonist of benzodiazepine activity
CAS Number:
74214-62-3
Purity:
≥97%
Molecular Weight:
240.3
Molecular Formula:
C14H12N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ethyl β-carboline-3-carboxylate is a polyaromatic small molecule isolable from human urine extracts, demonstrating anxiogenic effects as a partial inverse agonist of benzodiazepine activity at the GABAA receptors. β-carboline derivatives with a 3-position carbonyl functionality have demonstrated induction of convulsions and anxiogenesis comparable to the effects associated with cerebral electrolytic lesions. Ethyl β-carboline-3-carboxylate demonstrates displacement of diazepam from the benzodiazepine binding site.
Ethyl β-carboline-3-carboxylate (β-CCE) (CAS 74214-62-3) References
- Pontine tegmentum lesions increase anxiety-like behavior in rats: a comparison with anxiety produced by beta-CCE. | Podhorna, J. and Franklin, KB. 2000. Pharmacol Biochem Behav. 65: 267-73. PMID: 10672979
- Identification of a residue in the gamma-aminobutyric acid type A receptor alpha subunit that differentially affects diazepam-sensitive and -insensitive benzodiazepine site binding. | Derry, JM., et al. 2004. J Neurochem. 88: 1431-8. PMID: 15009644
- Effects of GABA modulators on the repeated acquisition of response sequences in squirrel monkeys. | Campbell, UC., et al. 2004. J Exp Anal Behav. 82: 37-56. PMID: 15484870
- Negative GABA(A) modulators attenuate the discriminative stimulus effects of benzodiazepines and the neuroactive steroid pregnanolone in rhesus monkeys. | McMahon, LR. and France, CP. 2005. Psychopharmacology (Berl). 181: 697-705. PMID: 15983789
- An inverse agonist selective for alpha5 subunit-containing GABAA receptors enhances cognition. | Dawson, GR., et al. 2006. J Pharmacol Exp Ther. 316: 1335-45. PMID: 16326923
- Efficacy and the discriminative stimulus effects of negative GABAA modulators, or inverse agonists, in diazepam-treated rhesus monkeys. | McMahon, LR., et al. 2006. J Pharmacol Exp Ther. 318: 907-13. PMID: 16705082
- Relative potency and effectiveness of flunitrazepam, ethanol, and beta-CCE for disrupting the acquisition and retention of response sequences in rats. | Leonard, ST., et al. 2009. Behav Pharmacol. 20: 33-44. PMID: 19179849
- Ethyl β-Carboline-3-Carboxylate Increases Cervical Cancer Cell Apoptosis Through ROS-p38 MAPK Signaling Pathway. | Sun, HN., et al. 2022. In Vivo. 36: 1178-1187. PMID: 35478127
- Peroxiredoxin 5 protects HepG2 cells from ethyl β-carboline-3-carboxylate-induced cell death via ROS-dependent MAPK signalling pathways. | Xie, DP., et al. 2022. J Cancer. 13: 3258-3267. PMID: 36118528
- Beta-carbolines: synthesis and neurochemical and pharmacological actions on brain benzodiazepine receptors. | Cain, M., et al. 1982. J Med Chem. 25: 1081-91. PMID: 6127411
- Urinary and brain beta-carboline-3-carboxylates as potent inhibitors of brain benzodiazepine receptors. | Braestrup, C., et al. 1980. Proc Natl Acad Sci U S A. 77: 2288-92. PMID: 6246535
- Anxiogenic and non-anxiogenic benzodiazepine antagonists. | Prado de Carvalho, LP., et al. 1983. Nature. 301: 64-6. PMID: 6296684
- beta-Carbolines as benzodiazepine receptor ligands. 1. Synthesis and benzodiazepine receptor interaction of esters of beta-carboline-3-carboxylic acid. | Lippke, KP., et al. 1983. J Med Chem. 26: 499-503. PMID: 6300400
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ethyl β-carboline-3-carboxylate (β-CCE), 100 mg | sc-200163 | 100 mg | $31.00 |