Date published: 2026-2-7

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Esomeprazole magnesium dihydrate (CAS 217087-10-0)

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Application:
Esomeprazole magnesium dihydrate is a proton pump inhibitor
CAS Number:
217087-10-0
Purity:
≥98%
Molecular Weight:
749.15
Molecular Formula:
C34H36MgN6O6S22H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Esomeprazole magnesium dihydrate is employed in research applications that focus on studying gastric acid secretion. The chemical acts as a proton pump inhibitor, inhibiting the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell. Because of this action, esomeprazole magnesium dihydrate is useful in research aimed at understanding the mechanisms of acid-related diseases and conditions. Additionally, it is used in studies that explore chemical interactions at the level of hepatic metabolism, as it is metabolized by the cytochrome P450 system. Researchers also investigate its impact on the bioavailability of other compounds, as esomeprazole magnesium dihydrate can affect the gastric pH and subsequently influence the absorption of certain substances in the stomach.


Esomeprazole magnesium dihydrate (CAS 217087-10-0) References

  1. Proton pump inhibitors to be used more?  |  Andrawiss, M. 2005. Drug Discov Today. 10: 607-8. PMID: 15894221
  2. Crystallization of Esomeprazole Magnesium Water/Butanol Solvate.  |  Skieneh, J., et al. 2016. Molecules. 21: 544. PMID: 27120591
  3. Esomeprazole immediate release tablets: Gastric mucosa ex vivo permeation, absorption and antisecretory activity in conscious rats.  |  Benetti, C., et al. 2016. J Control Release. 239: 203-10. PMID: 27574989
  4. Enhanced gastric stability of esomeprazole by molecular interaction and modulation of microenvironmental pH with alkalizers in solid dispersion.  |  Van Nguyen, H., et al. 2017. Int J Pharm. 523: 189-202. PMID: 28342789
  5. A fast, sensitive, and high throughput method for the determination of esomeprazole in dog plasma by UHPLC-MS/MS: Application to formulation development of the compound preparation of esomeprazole.  |  Liu, R., et al. 2017. J Chromatogr B Analyt Technol Biomed Life Sci. 1068-1069: 352-357. PMID: 29128277
  6. A sample wetting strategy to overcome differences in physical morphology between lab-prepared training samples and pharmaceutical process samples for reliable quantitative Raman spectroscopic analysis.  |  Lee, Y., et al. 2019. Analyst. 144: 2403-2410. PMID: 30809627
  7. Determination of Proton Pump Inhibitors by Spectrophotometric, Chromatographic and by Hyphenated Techniques: A Review.  |  Joshi, AA. and Nerkar, PP. 2021. Crit Rev Anal Chem. 51: 527-548. PMID: 32312104
  8. Simultaneous determination of naproxen and esomeprazole in beagle dog plasma by supercritical fluid chromatography-tandem mass spectrometry coupled with evaporation-free liquid-liquid extraction.  |  Yang, Y., et al. 2021. J Pharm Biomed Anal. 193: 113668. PMID: 33176242
  9. Chiral separation in the class of proton pump inhibitors by chromatographic and electromigration techniques: An overview.  |  Papp, LA., et al. 2021. Electrophoresis. 42: 1761-1789. PMID: 34004039
  10. Formulation of Dosage Forms with Proton Pump Inhibitors: State of the Art, Challenges and Future Perspectives.  |  Srebro, J., et al. 2022. Pharmaceutics. 14: PMID: 36297478

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Esomeprazole magnesium dihydrate, 50 mg

sc-252785
50 mg
$70.00