Molecular structure of Erythromycin A dihydrate, CAS Number: 59319-72-1
Erythromycin A dihydrate (CAS 59319-72-1)
CAS Number:
59319-72-1
Molecular Weight:
769.96
Molecular Formula:
C37H67NO13•2H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Erythromycin A dihydrate is extensively employed in biological research to explore its interaction with bacterial ribosomes. It serves as a useful tool for probing the structure and function of the ribosomal exit tunnel, where it is known to bind and inhibit protein synthesis. Studies involving Erythromycin A dihydrate often focus on the molecular basis of ribosome selectivity and the inhibition mechanism that leads to the cessation of bacterial growth. This compound is also utilized in investigating the development of bacterial resistance mechanisms. In addition, it facilitates the study of ribosome conformational changes upon antibiotic binding, which is for understanding the translational regulation in prokaryotic organisms.
Erythromycin A dihydrate (CAS 59319-72-1) References
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- Motilin and erythromycin-A share a common binding site in the third transmembrane segment of the motilin receptor. | Xu, L., et al. 2005. Biochem Pharmacol. 70: 879-87. PMID: 16076462
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- Erythromycin A dimethyl sulfoxide disolvate 1.43-hydrate. | Brüning, J., et al. 2012. Acta Crystallogr Sect E Struct Rep Online. 68: o700-1. PMID: 22412590
- Enhancement of the properties of a drug by mono-deuteriation: reduction of acid-catalysed formation of a gut-motilide enol ether from 8-deuterio-erythromycin B. | Bhadra, PK., et al. 2016. Org Biomol Chem. 14: 6289-96. PMID: 27273525
- Blocking the flow of propionate into TCA cycle through a mutB knockout leads to a significant increase of erythromycin production by an industrial strain of Saccharopolyspora erythraea. | Chen, C., et al. 2017. Bioprocess Biosyst Eng. 40: 201-209. PMID: 27709326
- Isolation and characterization of a high-efficiency erythromycin A-degrading Ochrobactrum sp. strain. | Zhang, W., et al. 2017. Mar Pollut Bull. 114: 896-902. PMID: 27863881
- High-throughput optimization of the chemically defined synthetic medium for the production of erythromycin A. | Hong, M., et al. 2018. Bioprocess Biosyst Eng. 41: 1529-1538. PMID: 30003380
- Study of the stability of erythromycin in a hydrophilic creme basis by liquid chromatography. | Paesen, J., et al. 1998. J Pharm Biomed Anal. 17: 53-6. PMID: 9608426
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Erythromycin A dihydrate, 250 mg | sc-234871 | 250 mg | $77.00 |