Molecular structure of Erlotinib-d6, Hydrochloride Salt
Erlotinib-d6, Hydrochloride Salt
See product citations (6)
Alternate Names:
Tarceva-d3; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy-d3)-4-quinazolinamine Hydrochloride
Application:
Erlotinib-d6, Hydrochloride Salt is a labeled form of Erlontinib HCl, a potent EGFR autophosphorylation inhibitior
Molecular Weight:
435.93
Molecular Formula:
C22H17D6N3O4•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Erlotinib-d6, Hydrochloride Salt potently inhibits EGFR autophosphorylation in cultured human head and neck tumor cells, a cell line which exhibits high levels of EGFR. Erlotinib-d6, Hydrochloride Salt also inhibits the proliferation of PC-9 cell lines, which contain a deletion mutation on exon 19 of the EGFR gene. A combination of Erlotinib-d6, Hydrochloride Salt and rapamycin produced a synergistic inhibitory effect on cell growth.
Erlotinib-d6, Hydrochloride Salt References
- Antisecretory Factor-Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma. | Ilkhanizadeh, S., et al. 2018. Mol Cancer Res. 16: 777-790. PMID: 29431617
- Quantification of the tyrosine kinase inhibitor erlotinib in human scalp hair by liquid chromatography-tandem mass spectrometry: Pitfalls for clinical application. | Braal, CL., et al. 2019. J Pharm Biomed Anal. 172: 175-182. PMID: 31051406
- Development of a rapid and sensitive UPLC-MS/MS assay for simultaneous quantitation of Vorolanib and its metabolite in human plasma and application to a pharmacokinetics study. | Zheng, X., et al. 2021. J Pharm Biomed Anal. 199: 114034. PMID: 33774456
- Determining plasma and cerebrospinal fluid concentrations of EGFR-TKI in lung cancer patients. | Chen, GY., et al. 2023. Anal Biochem. 669: 115115. PMID: 36931580
Inhibitor of:
EGFR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Erlotinib-d6, Hydrochloride Salt, 1 mg | sc-218329 | 1 mg | $265.00 |