epsin 2 Antibody (F-10): sc-376788

Epsin 2 Antibody (F-10) is a mouse monoclonal IgG3 kappa light chain antibody that detects epsin 2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-epsin 2 antibody (F-10) is available as a non-conjugated format. Epsin 2 plays a crucial role in Clathrin-mediated endocytosis, which is essential for internalizing various receptors and nutrients into cells. This process maintains cellular homeostasis and regulates signaling pathways, particularly those involving receptor tyrosine kinases (RTKs). Disruption of epsin function can lead to impaired endocytosis, potentially contributing to various diseases, including cancer, by affecting cellular response to growth factors and other stimuli. Epsin 2 interacts with Eps15, another key player in the endocytic pathway, and both proteins are predominantly found in presynaptic nerve terminals, highlighting their importance in synaptic vesicle recycling. Epsin 2 exists in two splicing variants, epsin 2a and 2b, which are enriched in the brain and localized in the peri-Golgi region, emphasizing epsin 2′s significance in neuronal function and signaling.

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epsin 2 Antibody (F-10) References:

1. The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15.  |  Sengar, AS., et al. 1999. EMBO J. 18: 1159-71. PMID: 10064583
2. The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module.  |  Rosenthal, JA., et al. 1999. J Biol Chem. 274: 33959-65. PMID: 10567358
3. Differential expression of epidermal growth factor-related proteins in human colorectal tumors.  |  Ciardiello, F., et al. 1991. Proc Natl Acad Sci U S A. 88: 7792-6. PMID: 1715580
4. Human transforming growth factors induce tyrosine phosphorylation of EGF receptors.  |  Reynolds, FH., et al. 1981. Nature. 292: 259-62. PMID: 6265789
5. eps15, a novel tyrosine kinase substrate, exhibits transforming activity.  |  Fazioli, F., et al. 1993. Mol Cell Biol. 13: 5814-28. PMID: 7689153
6. Eps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signals.  |  Fazioli, F., et al. 1993. EMBO J. 12: 3799-808. PMID: 8404850
7. Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis.  |  Chen, H., et al. 1998. Nature. 394: 793-7. PMID: 9723620
8. The interaction of epsin and Eps15 with the clathrin adaptor AP-2 is inhibited by mitotic phosphorylation and enhanced by stimulation-dependent dephosphorylation in nerve terminals.  |  Chen, H., et al. 1999. J Biol Chem. 274: 3257-60. PMID: 9920862

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-epsin 2 Antibody (F-10) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-epsin 2 Antibody (F-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

epsin 2 Antibody (F-10) Specifications

Alternate Product Name: epsin 2

Product Clone Name: F-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 551-578

Epitope Target: epsin 2

Epitope Species: human

Product Reactivity/Detection: epsin 2a and epsin 2b

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for epsin 2 Antibody (F-10): P: Blocking Peptide