Eps8 Antibody (D-4): sc-398643

Eps8 Antibody (D-4) is a mouse monoclonal IgG3 antibody that detects Eps8 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Eps8 plays a crucial role in cellular signaling pathways, particularly in the modulation of receptor tyrosine kinases (RTKs) that are essential for regulating cell growth and proliferation. Eps8 is primarily located at the plasma membrane, where Eps8 interacts with various signaling molecules, including the EGF receptor, to facilitate downstream signaling cascades. This localization allows Eps8 to respond rapidly to extracellular signals, thereby influencing cellular responses to growth factors. Notably, Eps8 contains both a pleckstrin homology (PH) domain and a Src homology 3 (SH3) domain, which are important for protein interactions and for mediating actin cytoskeleton remodeling. Dysregulation of Eps8 has been implicated in cellular transformation and cancer, making Eps8 a significant target for research in tumor biology. Anti-Eps8 antibody (D-4) is an invaluable tool for studying Eps8 dynamics in various biological contexts, providing insights into function and potential as a therapeutic target.

The preferred Eps8 antibody is Eps8 Antibody (F-8): sc-390257.